Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron (ii) triple helicates

Research output: Contribution to journalArticle


  • Y Parajo
  • J Malina
  • I Meistermann
  • GJ Clarkson
  • M Pascu
  • A Rodger

Colleges, School and Institutes


Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH(2). The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.


Original languageEnglish
Pages (from-to)4868-4874
Number of pages7
JournalDalton Trans
Publication statusPublished - 1 Jan 2007