Economic evaluation alongside factorial trials: a systematic review of empirical studies

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@article{5d9a2d4196a14da69f0b692d2d8a3d89,
title = "Economic evaluation alongside factorial trials: a systematic review of empirical studies",
abstract = "Although economic evaluations have been performed alongside factorial trials, there seems to be limited guidance/consensus on appropriate methods of analysis. Following Centre for Review and Dissemination guidance, a systematic review of published literature for all years was performed to explore how economic evaluation alongside factorial trials have been conducted and only full economic evaluations conducted alongside factorial trials were included. A total of 16 relevant studies were identified, and an assessment of these indicated that two methods: within-the-table and at-the-margins approaches were used for the analysis. With the exception of one study, all others did not consider interactions in costs and outcomes or give a detailed explanation of why a particular approach was adopted. The authors recommend that additional guidance is needed, and further research is required to evaluate the impact of alternative methods on policy recommendations and establish good practice methods for the economic analysis of factorial trials.",
keywords = "cost-benefit analysis, cost–effectiveness, cost-utility analysis, economic evaluation, factorial design, factorial trial",
author = "Samuel Frempong and Ilias Goranitis and Raymond Oppong",
year = "2015",
month = "8",
day = "7",
doi = "10.1586/14737167.2015.1076336",
language = "English",
volume = "15",
pages = "801--811",
journal = "Expert Review of Pharmacoeconomics & Outcomes Research",
issn = "1473-7167",
publisher = "Informa Healthcare",
number = "5",

}

RIS

TY - JOUR

T1 - Economic evaluation alongside factorial trials

T2 - a systematic review of empirical studies

AU - Frempong, Samuel

AU - Goranitis, Ilias

AU - Oppong, Raymond

PY - 2015/8/7

Y1 - 2015/8/7

N2 - Although economic evaluations have been performed alongside factorial trials, there seems to be limited guidance/consensus on appropriate methods of analysis. Following Centre for Review and Dissemination guidance, a systematic review of published literature for all years was performed to explore how economic evaluation alongside factorial trials have been conducted and only full economic evaluations conducted alongside factorial trials were included. A total of 16 relevant studies were identified, and an assessment of these indicated that two methods: within-the-table and at-the-margins approaches were used for the analysis. With the exception of one study, all others did not consider interactions in costs and outcomes or give a detailed explanation of why a particular approach was adopted. The authors recommend that additional guidance is needed, and further research is required to evaluate the impact of alternative methods on policy recommendations and establish good practice methods for the economic analysis of factorial trials.

AB - Although economic evaluations have been performed alongside factorial trials, there seems to be limited guidance/consensus on appropriate methods of analysis. Following Centre for Review and Dissemination guidance, a systematic review of published literature for all years was performed to explore how economic evaluation alongside factorial trials have been conducted and only full economic evaluations conducted alongside factorial trials were included. A total of 16 relevant studies were identified, and an assessment of these indicated that two methods: within-the-table and at-the-margins approaches were used for the analysis. With the exception of one study, all others did not consider interactions in costs and outcomes or give a detailed explanation of why a particular approach was adopted. The authors recommend that additional guidance is needed, and further research is required to evaluate the impact of alternative methods on policy recommendations and establish good practice methods for the economic analysis of factorial trials.

KW - cost-benefit analysis

KW - cost–effectiveness

KW - cost-utility analysis

KW - economic evaluation

KW - factorial design

KW - factorial trial

UR - http://www.tandfonline.com/doi/abs/10.1586/14737167.2015.1076336?journalCode=ierp20

U2 - 10.1586/14737167.2015.1076336

DO - 10.1586/14737167.2015.1076336

M3 - Article

VL - 15

SP - 801

EP - 811

JO - Expert Review of Pharmacoeconomics & Outcomes Research

JF - Expert Review of Pharmacoeconomics & Outcomes Research

SN - 1473-7167

IS - 5

ER -