Dysglycaemia, inflammation and psychosis: findings from the UK ALSPAC birth cohort

Research output: Contribution to journalArticlepeer-review

Standard

Dysglycaemia, inflammation and psychosis : findings from the UK ALSPAC birth cohort. / Perry, Benjamin Ian; Upthegrove, Rachel; Thompson, Andrew; Marwaha, Steven; Zammit, Stanley; Singh, Swaran Preet; Khandaker, Golam.

In: Schizophrenia bulletin, Vol. 45, No. 2, 03.2019, p. 330–338.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Perry, Benjamin Ian ; Upthegrove, Rachel ; Thompson, Andrew ; Marwaha, Steven ; Zammit, Stanley ; Singh, Swaran Preet ; Khandaker, Golam. / Dysglycaemia, inflammation and psychosis : findings from the UK ALSPAC birth cohort. In: Schizophrenia bulletin. 2019 ; Vol. 45, No. 2. pp. 330–338.

Bibtex

@article{b84463220fd444b1ba848f4b39af746b,
title = "Dysglycaemia, inflammation and psychosis: findings from the UK ALSPAC birth cohort",
abstract = "Background: Psychosis is associated with both dysglycaemia and low-grade inflammation, but population-based studies investigating the interplay between these factors are scarce.Aims: (1) To explore the direction of association between markers of dysglycaemia, inflammation and psychotic experiences (PEs); and (2) To explore whether dysglycaemia moderates and/or mediates the association between inflammation and PEs.Method: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were modeled using logistic and linear regression to examine cross-sectional and longitudinal associations between markers of dysglycaemia (ages 9 and 18), interleukin-6 (IL-6) (age 9), and PEs (ages 12 and 18). We tested for an interaction between dysglycaemia and IL-6 on risk of PEs at age 18, and tested whether dysglycaemia mediated the relationship between IL-6 and PEs.Results: Based on 2627 participants, at age 18, insulin resistance (IR) was associated with PEs (adjusted OR = 2.32; 95% CI, 1.37-3.97). IR was associated with IL-6 both cross-sectionally and longitudinally. Interaction analyses under a multiplicative model showed that IR moderated the association between IL-6 at age 9 and PEs at age 18 (adjusted OR for interaction term = 2.18; 95% C.I., 1.06-4.49). Mediation analysis did not support a model of IR mediating the relationship between IL-6 and PEs.Implications: IR is associated with PEs in young people even before the onset of clinical psychosis. Metabolic alterations may interact with childhood inflammation to increase risk of PEs. The findings have implications for clinical practice and future research.",
keywords = "dysglycaemia, insulin resistance, psychosis, risk, schizophrenia, inflammation, ALSPAC",
author = "Perry, {Benjamin Ian} and Rachel Upthegrove and Andrew Thompson and Steven Marwaha and Stanley Zammit and Singh, {Swaran Preet} and Golam Khandaker",
year = "2019",
month = mar,
doi = "10.1093/schbul/sby040",
language = "English",
volume = "45",
pages = "330–338",
journal = "Schizophrenia bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Dysglycaemia, inflammation and psychosis

T2 - findings from the UK ALSPAC birth cohort

AU - Perry, Benjamin Ian

AU - Upthegrove, Rachel

AU - Thompson, Andrew

AU - Marwaha, Steven

AU - Zammit, Stanley

AU - Singh, Swaran Preet

AU - Khandaker, Golam

PY - 2019/3

Y1 - 2019/3

N2 - Background: Psychosis is associated with both dysglycaemia and low-grade inflammation, but population-based studies investigating the interplay between these factors are scarce.Aims: (1) To explore the direction of association between markers of dysglycaemia, inflammation and psychotic experiences (PEs); and (2) To explore whether dysglycaemia moderates and/or mediates the association between inflammation and PEs.Method: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were modeled using logistic and linear regression to examine cross-sectional and longitudinal associations between markers of dysglycaemia (ages 9 and 18), interleukin-6 (IL-6) (age 9), and PEs (ages 12 and 18). We tested for an interaction between dysglycaemia and IL-6 on risk of PEs at age 18, and tested whether dysglycaemia mediated the relationship between IL-6 and PEs.Results: Based on 2627 participants, at age 18, insulin resistance (IR) was associated with PEs (adjusted OR = 2.32; 95% CI, 1.37-3.97). IR was associated with IL-6 both cross-sectionally and longitudinally. Interaction analyses under a multiplicative model showed that IR moderated the association between IL-6 at age 9 and PEs at age 18 (adjusted OR for interaction term = 2.18; 95% C.I., 1.06-4.49). Mediation analysis did not support a model of IR mediating the relationship between IL-6 and PEs.Implications: IR is associated with PEs in young people even before the onset of clinical psychosis. Metabolic alterations may interact with childhood inflammation to increase risk of PEs. The findings have implications for clinical practice and future research.

AB - Background: Psychosis is associated with both dysglycaemia and low-grade inflammation, but population-based studies investigating the interplay between these factors are scarce.Aims: (1) To explore the direction of association between markers of dysglycaemia, inflammation and psychotic experiences (PEs); and (2) To explore whether dysglycaemia moderates and/or mediates the association between inflammation and PEs.Method: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were modeled using logistic and linear regression to examine cross-sectional and longitudinal associations between markers of dysglycaemia (ages 9 and 18), interleukin-6 (IL-6) (age 9), and PEs (ages 12 and 18). We tested for an interaction between dysglycaemia and IL-6 on risk of PEs at age 18, and tested whether dysglycaemia mediated the relationship between IL-6 and PEs.Results: Based on 2627 participants, at age 18, insulin resistance (IR) was associated with PEs (adjusted OR = 2.32; 95% CI, 1.37-3.97). IR was associated with IL-6 both cross-sectionally and longitudinally. Interaction analyses under a multiplicative model showed that IR moderated the association between IL-6 at age 9 and PEs at age 18 (adjusted OR for interaction term = 2.18; 95% C.I., 1.06-4.49). Mediation analysis did not support a model of IR mediating the relationship between IL-6 and PEs.Implications: IR is associated with PEs in young people even before the onset of clinical psychosis. Metabolic alterations may interact with childhood inflammation to increase risk of PEs. The findings have implications for clinical practice and future research.

KW - dysglycaemia

KW - insulin resistance

KW - psychosis

KW - risk

KW - schizophrenia

KW - inflammation

KW - ALSPAC

U2 - 10.1093/schbul/sby040

DO - 10.1093/schbul/sby040

M3 - Article

C2 - 29635418

VL - 45

SP - 330

EP - 338

JO - Schizophrenia bulletin

JF - Schizophrenia bulletin

SN - 0586-7614

IS - 2

ER -