Dynamics of pneumococcal colonization in healthy Dutch children

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Dynamics of pneumococcal colonization in healthy Dutch children. / Bogaert, D; Sluijter, M; Toom, N Lemmens-den; Mitchell, T J; Goessens, W H F; Clarke, S C; de Groot, R; Hermans, P W M.

In: Microbiology, Vol. 152, No. Pt 2, 02.2006, p. 377-85.

Research output: Contribution to journalArticlepeer-review

Harvard

Bogaert, D, Sluijter, M, Toom, NL, Mitchell, TJ, Goessens, WHF, Clarke, SC, de Groot, R & Hermans, PWM 2006, 'Dynamics of pneumococcal colonization in healthy Dutch children', Microbiology, vol. 152, no. Pt 2, pp. 377-85. https://doi.org/10.1099/mic.0.28394-0

APA

Bogaert, D., Sluijter, M., Toom, N. L., Mitchell, T. J., Goessens, W. H. F., Clarke, S. C., de Groot, R., & Hermans, P. W. M. (2006). Dynamics of pneumococcal colonization in healthy Dutch children. Microbiology, 152(Pt 2), 377-85. https://doi.org/10.1099/mic.0.28394-0

Vancouver

Bogaert D, Sluijter M, Toom NL, Mitchell TJ, Goessens WHF, Clarke SC et al. Dynamics of pneumococcal colonization in healthy Dutch children. Microbiology. 2006 Feb;152(Pt 2):377-85. https://doi.org/10.1099/mic.0.28394-0

Author

Bogaert, D ; Sluijter, M ; Toom, N Lemmens-den ; Mitchell, T J ; Goessens, W H F ; Clarke, S C ; de Groot, R ; Hermans, P W M. / Dynamics of pneumococcal colonization in healthy Dutch children. In: Microbiology. 2006 ; Vol. 152, No. Pt 2. pp. 377-85.

Bibtex

@article{0422d4bb2cc84683a42632adedbf7284,
title = "Dynamics of pneumococcal colonization in healthy Dutch children",
abstract = "A recent study of pneumococcal colonization in 3198 healthy children of 1-19 years of age in The Netherlands showed pneumococcal colonization in 19 % of the children, with a peak incidence of 55 % at the age of 2 years; an age-related serotype distribution was also found. In the present study, the genetic background and resistance profiles of 578 pneumococcal isolates from the latter study were characterized by means of chromosomal genotyping and susceptibility testing. In contrast to the age-related serotype distribution observed previously, the genetic background of the strains was not age related. Few strains were found showing close homology (>95 %) with the international clones Spain(9V)-3 (ten isolates showed homology), England(14)-9 (four isolates), Tennessee(23F)-4 (two isolates), CSR(14)-10 (one isolate) and Sweden(15A)-25 (one isolate). In total, 19 % of strains showed resistance to one or more antibiotics. Resistance to cotrimoxazole, tetracycline, erythromycin and penicillin was found in 12.9, 5.6, 5.0 and 2.7 % of isolates, respectively. Multidrug resistance was found in 1.9 % of strains. In conclusion, pneumococcal colonization isolates from healthy Dutch children represent a heterogeneous, mostly antibiotic susceptible, genetic population.",
keywords = "Adolescent, Anti-Bacterial Agents, Child, Child, Preschool, Drug Resistance, Multiple, Bacterial, Female, Humans, Male, Nasopharynx, Netherlands, Phylogeny, Pneumococcal Infections, Serotyping, Streptococcus pneumoniae",
author = "D Bogaert and M Sluijter and Toom, {N Lemmens-den} and Mitchell, {T J} and Goessens, {W H F} and Clarke, {S C} and {de Groot}, R and Hermans, {P W M}",
year = "2006",
month = feb,
doi = "10.1099/mic.0.28394-0",
language = "English",
volume = "152",
pages = "377--85",
journal = "Microbiology",
issn = "1350-0872",
publisher = "Society for General Microbiology",
number = "Pt 2",

}

RIS

TY - JOUR

T1 - Dynamics of pneumococcal colonization in healthy Dutch children

AU - Bogaert, D

AU - Sluijter, M

AU - Toom, N Lemmens-den

AU - Mitchell, T J

AU - Goessens, W H F

AU - Clarke, S C

AU - de Groot, R

AU - Hermans, P W M

PY - 2006/2

Y1 - 2006/2

N2 - A recent study of pneumococcal colonization in 3198 healthy children of 1-19 years of age in The Netherlands showed pneumococcal colonization in 19 % of the children, with a peak incidence of 55 % at the age of 2 years; an age-related serotype distribution was also found. In the present study, the genetic background and resistance profiles of 578 pneumococcal isolates from the latter study were characterized by means of chromosomal genotyping and susceptibility testing. In contrast to the age-related serotype distribution observed previously, the genetic background of the strains was not age related. Few strains were found showing close homology (>95 %) with the international clones Spain(9V)-3 (ten isolates showed homology), England(14)-9 (four isolates), Tennessee(23F)-4 (two isolates), CSR(14)-10 (one isolate) and Sweden(15A)-25 (one isolate). In total, 19 % of strains showed resistance to one or more antibiotics. Resistance to cotrimoxazole, tetracycline, erythromycin and penicillin was found in 12.9, 5.6, 5.0 and 2.7 % of isolates, respectively. Multidrug resistance was found in 1.9 % of strains. In conclusion, pneumococcal colonization isolates from healthy Dutch children represent a heterogeneous, mostly antibiotic susceptible, genetic population.

AB - A recent study of pneumococcal colonization in 3198 healthy children of 1-19 years of age in The Netherlands showed pneumococcal colonization in 19 % of the children, with a peak incidence of 55 % at the age of 2 years; an age-related serotype distribution was also found. In the present study, the genetic background and resistance profiles of 578 pneumococcal isolates from the latter study were characterized by means of chromosomal genotyping and susceptibility testing. In contrast to the age-related serotype distribution observed previously, the genetic background of the strains was not age related. Few strains were found showing close homology (>95 %) with the international clones Spain(9V)-3 (ten isolates showed homology), England(14)-9 (four isolates), Tennessee(23F)-4 (two isolates), CSR(14)-10 (one isolate) and Sweden(15A)-25 (one isolate). In total, 19 % of strains showed resistance to one or more antibiotics. Resistance to cotrimoxazole, tetracycline, erythromycin and penicillin was found in 12.9, 5.6, 5.0 and 2.7 % of isolates, respectively. Multidrug resistance was found in 1.9 % of strains. In conclusion, pneumococcal colonization isolates from healthy Dutch children represent a heterogeneous, mostly antibiotic susceptible, genetic population.

KW - Adolescent

KW - Anti-Bacterial Agents

KW - Child

KW - Child, Preschool

KW - Drug Resistance, Multiple, Bacterial

KW - Female

KW - Humans

KW - Male

KW - Nasopharynx

KW - Netherlands

KW - Phylogeny

KW - Pneumococcal Infections

KW - Serotyping

KW - Streptococcus pneumoniae

U2 - 10.1099/mic.0.28394-0

DO - 10.1099/mic.0.28394-0

M3 - Article

C2 - 16436426

VL - 152

SP - 377

EP - 385

JO - Microbiology

JF - Microbiology

SN - 1350-0872

IS - Pt 2

ER -