Dynamic temporal and spatial regulation of the cdk inhibitor p57kip2 during embryo morphogenesis

J Westbury; M Watkins; A Ferguson-Smith; Janet Smith

doi:10.1016/S0925-4773(01)00512-3

Dynamic temporal and spatial regulation of the cdk inhibitor p57kip2 during embryo morphogenesis

J Westbury, M Watkins, A Ferguson-Smith, Janet Smith

Biosciences

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35 Citations (Scopus)

Abstract

The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.

Original language	English
Pages (from-to)	83-89
Number of pages	7
Journal	Mechanisms of Development
Volume	109
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4773(01)00512-3
Publication status	Published - 1 Nov 2001

Keywords

genomic imprinting
organogenesis
localization
apoptosis
cyclin dependent kinase inhibitor
programmed cell death
insulin-like growth factor
Beckwith-Weidemann syndrome
embryonic
cell cycle
skeletal muscle
p57kip2
embryogenesis
cell cycle control
morphogenesis
placenta
omphalocele
kidney
protein distribution
mouse development
mosaicism
lung development

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10.1016/S0925-4773(01)00512-3

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title = "Dynamic temporal and spatial regulation of the cdk inhibitor p57kip2 during embryo morphogenesis",

abstract = "The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.",

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author = "J Westbury and M Watkins and A Ferguson-Smith and Janet Smith",

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T1 - Dynamic temporal and spatial regulation of the cdk inhibitor p57kip2 during embryo morphogenesis

AU - Westbury, J

AU - Watkins, M

AU - Ferguson-Smith, A

AU - Smith, Janet

PY - 2001/11/1

Y1 - 2001/11/1

N2 - The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.

AB - The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.

KW - genomic imprinting

KW - organogenesis

KW - localization

KW - apoptosis

KW - cyclin dependent kinase inhibitor

KW - programmed cell death

KW - insulin-like growth factor

KW - Beckwith-Weidemann syndrome

KW - embryonic

KW - cell cycle

KW - skeletal muscle

KW - p57kip2

KW - embryogenesis

KW - cell cycle control

KW - morphogenesis

KW - placenta

KW - omphalocele

KW - kidney

KW - protein distribution

KW - mouse development

KW - mosaicism

KW - lung development

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U2 - 10.1016/S0925-4773(01)00512-3

DO - 10.1016/S0925-4773(01)00512-3

M3 - Article

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VL - 109

SP - 83

EP - 89

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1

ER -

Dynamic temporal and spatial regulation of the cdk inhibitor p57kip2 during embryo morphogenesis

Abstract

Keywords

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