Dynamic temporal and spatial regulation of the cdk inhibitor p57kip2 during embryo morphogenesis

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.

Details

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalMechanisms of Development
Volume109
Issue number1
Publication statusPublished - 1 Nov 2001

Keywords

  • genomic imprinting, organogenesis, localization, apoptosis, cyclin dependent kinase inhibitor, programmed cell death, insulin-like growth factor, Beckwith-Weidemann syndrome, embryonic, cell cycle, skeletal muscle, p57kip2, embryogenesis, cell cycle control, morphogenesis, placenta, omphalocele, kidney, protein distribution, mouse development, mosaicism, lung development