Dynamic fungal cell wall architecture in stress adaptation and immune evasion

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Dynamic fungal cell wall architecture in stress adaptation and immune evasion. / Hopke, Alex; Brown, Alister; Hall, Rebecca; Wheeler, Robert.

In: Trends in Microbiology, Vol. 26, No. 4, 13.02.2018, p. 284-295.

Research output: Contribution to journalReview articlepeer-review

Harvard

Hopke, A, Brown, A, Hall, R & Wheeler, R 2018, 'Dynamic fungal cell wall architecture in stress adaptation and immune evasion', Trends in Microbiology, vol. 26, no. 4, pp. 284-295.

APA

Vancouver

Author

Hopke, Alex ; Brown, Alister ; Hall, Rebecca ; Wheeler, Robert. / Dynamic fungal cell wall architecture in stress adaptation and immune evasion. In: Trends in Microbiology. 2018 ; Vol. 26, No. 4. pp. 284-295.

Bibtex

@article{b37bfdd2d8c646599285236d8dcb6e6b,
title = "Dynamic fungal cell wall architecture in stress adaptation and immune evasion",
abstract = "Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.",
author = "Alex Hopke and Alister Brown and Rebecca Hall and Robert Wheeler",
year = "2018",
month = feb,
day = "13",
language = "English",
volume = "26",
pages = "284--295",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Dynamic fungal cell wall architecture in stress adaptation and immune evasion

AU - Hopke, Alex

AU - Brown, Alister

AU - Hall, Rebecca

AU - Wheeler, Robert

PY - 2018/2/13

Y1 - 2018/2/13

N2 - Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.

AB - Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.

M3 - Review article

VL - 26

SP - 284

EP - 295

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 4

ER -