Dual role for phenylalanine 178 during catalysis by aristolochene synthase

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of alpha- and beta-farnesene as well as alpha and beta-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.

Details

Original languageEnglish
Pages (from-to)2094-2095
Number of pages2
JournalChemical Communications
Issue number18
Publication statusPublished - 1 Jan 2004