Abstract
The effect of the non-phenothiazine calmodulin-inhibitor R 24571 on transmitter release at the frog neuromuscular junction has been investigated. MEPP frequency was reduced by 25-40% at low concentrations of the drug (2-5 X 10(-7) M) but increased at higher concentrations. These effects were independent of [Ca2+]o. EPP quantal content was increased at low levels of release (quantal content 0.5-1.5) and was unaffected at higher levels (quantal content 30-40). It is concluded that R 24571 has both inhibitory and stimulatory effects, but that evoked release of transmitter is insensitive to the inhibitory action of the drug.
Original language | English |
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Pages (from-to) | 192-6 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 348 |
Issue number | 1 |
Publication status | Published - 25 Nov 1985 |
Keywords
- Animals
- Calcium
- Imidazoles
- In Vitro Techniques
- Membrane Potentials
- Neuromuscular Junction
- Rana temporaria
- Synaptic Transmission