Drug-induced inflammatory bowel disease and IBD-like conditions

Research output: Contribution to journalArticle

Authors

  • Marie-France Dubeau
  • Paul L Beck
  • Gordon W Moran
  • Gilaad G Kaplan
  • Remo Panaccione

Colleges, School and Institutes

External organisations

  • Inflammatory Bowel Disease Clinic and the Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada.

Abstract

The pathogenesis of inflammatory bowel disease (IBD) is multifactorial and results from an interaction between genetic, immunologic, microbial, and environmental factors. Certain drugs could act as a trigger for the disease and have been implicated in the development of new onset IBD in a number a studies. These relationships are based on case reports and cohort studies, as proving this in the context of randomized controlled trials would be difficult. Drugs that have been linked to causing or worsening IBD include isotretinoin, antibiotics, nonsteroidal antiinflammatory drugs, oral contraceptives, mycophenolate mofetil, etanercept, ipilimumab, and rituximab. Bowel preparation for colonoscopy has also been associated with aphthoid lesions that may be confused with IBD. However, given the source of these reports we have to be cautious in the interpretation of the data before concluding that these drugs trigger IBD and what is being observed is not related to other confounding factors. Different pathogenic mechanisms have been suggested for the different drugs listed above. In order to clarify the confusion a comprehensive literature review was performed with the goal of advancing the knowledge on this subject.

Details

Original languageEnglish
Pages (from-to)445-56
Number of pages12
JournalInflammatory Bowel Diseases
Volume19
Issue number2
Publication statusPublished - Feb 2013

Keywords

  • Anti-Bacterial Agents, Anti-Inflammatory Agents, Non-Steroidal, Cathartics, Contraceptives, Oral, Hormonal, Dermatologic Agents, Diagnosis, Differential, Endoscopy, Gastrointestinal, Humans, Immunosuppressive Agents, Inflammatory Bowel Diseases, Isotretinoin, Journal Article, Review