Dressed to impress : impact of environmental adaptation on the Candida albicans cell wall

Research output: Contribution to journalArticlepeer-review

Standard

Dressed to impress : impact of environmental adaptation on the Candida albicans cell wall. / Hall, Rebecca A.

In: Molecular Microbiology, Vol. 97, No. 1, 25.06.2015, p. 7-17.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{e96e85c4bf7340e89fac8a38fa346735,
title = "Dressed to impress : impact of environmental adaptation on the Candida albicans cell wall",
abstract = "Candida albicans is an opportunistic fungal pathogen of humans causing superficial mucosal infections and life-threatening systemic disease. The fungal cell wall is the first point of contact between the invading pathogen and the host innate immune system. As a result, the polysaccharides that comprise the cell wall act as pathogen associated molecular patterns, which govern the host–pathogen interaction. The cell wall is dynamic and responsive to changes in the external environment. Therefore, the host environment plays a critical role in regulating the host–pathogen interaction through modulation of the fungal cell wall. This review focuses on how environmental adaptation modulates the cell wall structure and composition, and the subsequent impact this has on the innate immune recognition of C. albicans.",
author = "Hall, {Rebecca A.}",
year = "2015",
month = jun,
day = "25",
doi = "10.1111/mmi.13020",
language = "English",
volume = "97",
pages = "7--17",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Dressed to impress : impact of environmental adaptation on the Candida albicans cell wall

AU - Hall, Rebecca A.

PY - 2015/6/25

Y1 - 2015/6/25

N2 - Candida albicans is an opportunistic fungal pathogen of humans causing superficial mucosal infections and life-threatening systemic disease. The fungal cell wall is the first point of contact between the invading pathogen and the host innate immune system. As a result, the polysaccharides that comprise the cell wall act as pathogen associated molecular patterns, which govern the host–pathogen interaction. The cell wall is dynamic and responsive to changes in the external environment. Therefore, the host environment plays a critical role in regulating the host–pathogen interaction through modulation of the fungal cell wall. This review focuses on how environmental adaptation modulates the cell wall structure and composition, and the subsequent impact this has on the innate immune recognition of C. albicans.

AB - Candida albicans is an opportunistic fungal pathogen of humans causing superficial mucosal infections and life-threatening systemic disease. The fungal cell wall is the first point of contact between the invading pathogen and the host innate immune system. As a result, the polysaccharides that comprise the cell wall act as pathogen associated molecular patterns, which govern the host–pathogen interaction. The cell wall is dynamic and responsive to changes in the external environment. Therefore, the host environment plays a critical role in regulating the host–pathogen interaction through modulation of the fungal cell wall. This review focuses on how environmental adaptation modulates the cell wall structure and composition, and the subsequent impact this has on the innate immune recognition of C. albicans.

U2 - 10.1111/mmi.13020

DO - 10.1111/mmi.13020

M3 - Article

C2 - 25846717

VL - 97

SP - 7

EP - 17

JO - Molecular Microbiology

JF - Molecular Microbiology

SN - 0950-382X

IS - 1

ER -