Dominant Role of the Protein-Tyrosine Phosphatase CD148 in Regulating Platelet Activation Relative to Protein-Tyrosine Phosphatase-1B

Jun Mori; Ying-Jie Wang; Stuart Ellison; Silke Heising; Benjamin G Neel; Michel L Tremblay; Steve P Watson; Yotis A Senis

doi:10.1161/ATVBAHA.112.300447

Dominant Role of the Protein-Tyrosine Phosphatase CD148 in Regulating Platelet Activation Relative to Protein-Tyrosine Phosphatase-1B

Jun Mori, Ying-Jie Wang, Stuart Ellison, Silke Heising, Benjamin G Neel, Michel L Tremblay, Steve P Watson, Yotis A Senis

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The receptor-like protein-tyrosine phosphatase (PTP) CD148 and the nontransmembrane PTP1-B have been shown to be net positive regulators of Src family kinases in platelets. In the present study, we compared the relative contributions of these PTPs in platelet activation by the major glycoprotein, glycoprotein VI, α(IIb)β(3), and C-type lectin-like receptor 2 (CLEC-2).

Original language	English
Pages (from-to)	2956-65
Number of pages	10
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	32
Issue number	12
DOIs	https://doi.org/10.1161/ATVBAHA.112.300447
Publication status	Published - 2012

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10.1161/ATVBAHA.112.300447

Regulation of Src Family Kinases in Platelets by the Kinase-Phosphatase Pair Csk-CD148
Senis, Y. & Watson, S.
British Heart Foundation
1/01/12 → 31/12/14
Project: Research

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title = "Dominant Role of the Protein-Tyrosine Phosphatase CD148 in Regulating Platelet Activation Relative to Protein-Tyrosine Phosphatase-1B",

abstract = "The receptor-like protein-tyrosine phosphatase (PTP) CD148 and the nontransmembrane PTP1-B have been shown to be net positive regulators of Src family kinases in platelets. In the present study, we compared the relative contributions of these PTPs in platelet activation by the major glycoprotein, glycoprotein VI, α(IIb)β(3), and C-type lectin-like receptor 2 (CLEC-2).",

author = "Jun Mori and Ying-Jie Wang and Stuart Ellison and Silke Heising and Neel, {Benjamin G} and Tremblay, {Michel L} and Watson, {Steve P} and Senis, {Yotis A}",

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T1 - Dominant Role of the Protein-Tyrosine Phosphatase CD148 in Regulating Platelet Activation Relative to Protein-Tyrosine Phosphatase-1B

AU - Mori, Jun

AU - Wang, Ying-Jie

AU - Ellison, Stuart

AU - Heising, Silke

AU - Neel, Benjamin G

AU - Tremblay, Michel L

AU - Watson, Steve P

AU - Senis, Yotis A

PY - 2012

Y1 - 2012

N2 - The receptor-like protein-tyrosine phosphatase (PTP) CD148 and the nontransmembrane PTP1-B have been shown to be net positive regulators of Src family kinases in platelets. In the present study, we compared the relative contributions of these PTPs in platelet activation by the major glycoprotein, glycoprotein VI, α(IIb)β(3), and C-type lectin-like receptor 2 (CLEC-2).

AB - The receptor-like protein-tyrosine phosphatase (PTP) CD148 and the nontransmembrane PTP1-B have been shown to be net positive regulators of Src family kinases in platelets. In the present study, we compared the relative contributions of these PTPs in platelet activation by the major glycoprotein, glycoprotein VI, α(IIb)β(3), and C-type lectin-like receptor 2 (CLEC-2).

U2 - 10.1161/ATVBAHA.112.300447

DO - 10.1161/ATVBAHA.112.300447

M3 - Article

C2 - 23065825

SN - 1524-4636

VL - 32

SP - 2956

EP - 2965

JO - Arteriosclerosis Thrombosis and Vascular Biology

JF - Arteriosclerosis Thrombosis and Vascular Biology

IS - 12

ER -

Dominant Role of the Protein-Tyrosine Phosphatase CD148 in Regulating Platelet Activation Relative to Protein-Tyrosine Phosphatase-1B

Abstract

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Regulation of Src Family Kinases in Platelets by the Kinase-Phosphatase Pair Csk-CD148

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