Does immunosuppressant medication lower blood pressure and arterial stiffness in patients with chronic kidney disease? An observational study.

Charles Ferro; Nicola Edwards; Colin Hutchison; P Cockwell; Richard Steeds; Caroline Savage; Jonathan Townend; Lorraine Harper

doi:10.1038/hr.2010.193

Does immunosuppressant medication lower blood pressure and arterial stiffness in patients with chronic kidney disease? An observational study.

Charles Ferro, Nicola Edwards, Colin Hutchison, P Cockwell, Richard Steeds, Caroline Savage, Jonathan Townend, Lorraine Harper

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Abstract

Chronic kidney disease is a proinflammatory state associated with increased arterial stiffness. We hypothesized that chronic kidney disease patients on long-term immunosuppression would have lower arterial stiffness and require treatment with less antihypertensive medication compared with non-immunosuppressed patients. A total of 254 patients (97 on immunosuppression) with chronic kidney disease were recruited from specialist renal clinics. Brachial blood pressure, central aortic pressure and waveform and pulse wave velocity were measured. Age, peripheral blood pressure and pulse wave velocity increased with worsening renal function but were not different between immunosuppressed and non-immunosuppressed patients. Central systolic (P

Original language	English
Journal	Hypertension Research
DOIs	https://doi.org/10.1038/hr.2010.193
Publication status	Published - 21 Oct 2010

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abstract = "Chronic kidney disease is a proinflammatory state associated with increased arterial stiffness. We hypothesized that chronic kidney disease patients on long-term immunosuppression would have lower arterial stiffness and require treatment with less antihypertensive medication compared with non-immunosuppressed patients. A total of 254 patients (97 on immunosuppression) with chronic kidney disease were recruited from specialist renal clinics. Brachial blood pressure, central aortic pressure and waveform and pulse wave velocity were measured. Age, peripheral blood pressure and pulse wave velocity increased with worsening renal function but were not different between immunosuppressed and non-immunosuppressed patients. Central systolic (P",

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AU - Ferro, Charles

AU - Edwards, Nicola

AU - Hutchison, Colin

AU - Cockwell, P

AU - Steeds, Richard

AU - Savage, Caroline

AU - Townend, Jonathan

AU - Harper, Lorraine

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AB - Chronic kidney disease is a proinflammatory state associated with increased arterial stiffness. We hypothesized that chronic kidney disease patients on long-term immunosuppression would have lower arterial stiffness and require treatment with less antihypertensive medication compared with non-immunosuppressed patients. A total of 254 patients (97 on immunosuppression) with chronic kidney disease were recruited from specialist renal clinics. Brachial blood pressure, central aortic pressure and waveform and pulse wave velocity were measured. Age, peripheral blood pressure and pulse wave velocity increased with worsening renal function but were not different between immunosuppressed and non-immunosuppressed patients. Central systolic (P

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Does immunosuppressant medication lower blood pressure and arterial stiffness in patients with chronic kidney disease? An observational study.

Abstract

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