Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
Research output: Contribution to journal › Article
Colleges, School and Institutes
Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP). Mutant hIAPP with iso-aspartic residue mutations at possible deamidation sites showed very different fibril formation behaviour, which correlates with the observed deamidation-induced acceleration of hIAPP aggregation.
|Number of pages||4|
|Publication status||Published - 19 Nov 2018|