Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort?

Research output: Contribution to journalArticlepeer-review


  • Andrew Thompson
  • Barnaby Nelson
  • Patrick D McGorry
  • Alison R Yung
  • Ashleigh Lin

Colleges, School and Institutes

External organisations

  • Orygen, The National Centre of Excellence in Youth Mental Health
  • University of Manchester
  • University of Western Australia
  • University of Melbourne
  • University of Warwick


We have previously reported an association between childhood sexual trauma and transition to psychosis in an Ultra High Risk (UHR) population. We aimed to investigate if this association was mediated by affective or dissociative symptoms. Data were from a large UHR for psychosis cohort study. None of the potential mediators (depression, anxiety, dissociation, mood swings and mania, assessed by the HAM-D, HAM-A and the CAARMS symptom scales) significantly mediated the total association between sexual abuse scores and transition. At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms.


Original languageEnglish
Pages (from-to)182-185
Number of pages4
JournalPsychiatry Research
Publication statusPublished - 28 Feb 2016


  • Adolescent, Adult, Affective Symptoms/psychology, Anxiety/psychology, Bipolar Disorder/psychology, Child, Child Abuse, Sexual/psychology, Cohort Studies, Depression/psychology, Dissociative Disorders/psychology, Female, Humans, Male, Mood Disorders/psychology, Psychotic Disorders/psychology, Risk, Young Adult