DNA sequence properties that predict susceptibility to epiallelic switching

Research output: Contribution to journalArticlepeer-review

Standard

DNA sequence properties that predict susceptibility to epiallelic switching. / Catoni, Marco; Griffiths, Jayne; Becker, Claude; Zabet, Nicolae Radu; Bayon, Carlos; Dapp , Mélanie; Lieberman-Lazarovich, Michal; Weigel, Detlef; Paszkowski, Jerzy.

In: The EMBO journal, Vol. 36, No. 5, 01.03.2017, p. 617-628.

Research output: Contribution to journalArticlepeer-review

Harvard

Catoni, M, Griffiths, J, Becker, C, Zabet, NR, Bayon, C, Dapp , M, Lieberman-Lazarovich, M, Weigel, D & Paszkowski, J 2017, 'DNA sequence properties that predict susceptibility to epiallelic switching', The EMBO journal, vol. 36, no. 5, pp. 617-628. https://doi.org/10.15252/embj.201695602

APA

Catoni, M., Griffiths, J., Becker, C., Zabet, N. R., Bayon, C., Dapp , M., Lieberman-Lazarovich, M., Weigel, D., & Paszkowski, J. (2017). DNA sequence properties that predict susceptibility to epiallelic switching. The EMBO journal, 36(5), 617-628. https://doi.org/10.15252/embj.201695602

Vancouver

Author

Catoni, Marco ; Griffiths, Jayne ; Becker, Claude ; Zabet, Nicolae Radu ; Bayon, Carlos ; Dapp , Mélanie ; Lieberman-Lazarovich, Michal ; Weigel, Detlef ; Paszkowski, Jerzy. / DNA sequence properties that predict susceptibility to epiallelic switching. In: The EMBO journal. 2017 ; Vol. 36, No. 5. pp. 617-628.

Bibtex

@article{5af49cc6bf044568b647804a7f5bb78e,
title = "DNA sequence properties that predict susceptibility to epiallelic switching",
abstract = "Transgenerationally heritable epialleles are defined by the stable propagation of alternative transcriptional states through mitotic and meiotic cell cycles. Given that the propagation of DNA methylation at CpG sites, mediated in Arabidopsis by MET1, plays a central role in epigenetic inheritance, we examined genomewide DNA methylation in partial and complete loss-of-function met1 mutants. We interpreted the data in relation to transgenerational epiallelic stability, which allowed us to classify chromosomal targets of epigenetic regulation into (i) single copy and methylated exclusively at CpGs, readily forming epialleles, and (ii) transposon-derived, methylated at all cytosines, which may or may not form epialleles. We provide evidence that DNA sequence features such as density of CpGs and genomic repetitiveness of the loci predispose their susceptibility to epiallelic switching. The importance and predictive power of these genetic features were confirmed by analyses of common epialleles in natural Arabidopsis accessions, epigenetic recombinant inbred lines (epiRILs) and also verified in rice.",
keywords = "Arabidopsis/genetics, Arabidopsis Proteins/genetics, DNA (Cytosine-5-)-Methyltransferases/genetics, DNA Methylation, DNA, Plant/chemistry, Epigenesis, Genetic, Gene Expression Regulation, Plant, Mutation",
author = "Marco Catoni and Jayne Griffiths and Claude Becker and Zabet, {Nicolae Radu} and Carlos Bayon and M{\'e}lanie Dapp and Michal Lieberman-Lazarovich and Detlef Weigel and Jerzy Paszkowski",
note = "{\textcopyright} 2017 The Authors. Published under the terms of the CC BY NC ND 4.0 license.",
year = "2017",
month = mar,
day = "1",
doi = "10.15252/embj.201695602",
language = "English",
volume = "36",
pages = "617--628",
journal = "The EMBO journal",
issn = "0261-4189",
publisher = "EMBO Press",
number = "5",

}

RIS

TY - JOUR

T1 - DNA sequence properties that predict susceptibility to epiallelic switching

AU - Catoni, Marco

AU - Griffiths, Jayne

AU - Becker, Claude

AU - Zabet, Nicolae Radu

AU - Bayon, Carlos

AU - Dapp , Mélanie

AU - Lieberman-Lazarovich, Michal

AU - Weigel, Detlef

AU - Paszkowski, Jerzy

N1 - © 2017 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Transgenerationally heritable epialleles are defined by the stable propagation of alternative transcriptional states through mitotic and meiotic cell cycles. Given that the propagation of DNA methylation at CpG sites, mediated in Arabidopsis by MET1, plays a central role in epigenetic inheritance, we examined genomewide DNA methylation in partial and complete loss-of-function met1 mutants. We interpreted the data in relation to transgenerational epiallelic stability, which allowed us to classify chromosomal targets of epigenetic regulation into (i) single copy and methylated exclusively at CpGs, readily forming epialleles, and (ii) transposon-derived, methylated at all cytosines, which may or may not form epialleles. We provide evidence that DNA sequence features such as density of CpGs and genomic repetitiveness of the loci predispose their susceptibility to epiallelic switching. The importance and predictive power of these genetic features were confirmed by analyses of common epialleles in natural Arabidopsis accessions, epigenetic recombinant inbred lines (epiRILs) and also verified in rice.

AB - Transgenerationally heritable epialleles are defined by the stable propagation of alternative transcriptional states through mitotic and meiotic cell cycles. Given that the propagation of DNA methylation at CpG sites, mediated in Arabidopsis by MET1, plays a central role in epigenetic inheritance, we examined genomewide DNA methylation in partial and complete loss-of-function met1 mutants. We interpreted the data in relation to transgenerational epiallelic stability, which allowed us to classify chromosomal targets of epigenetic regulation into (i) single copy and methylated exclusively at CpGs, readily forming epialleles, and (ii) transposon-derived, methylated at all cytosines, which may or may not form epialleles. We provide evidence that DNA sequence features such as density of CpGs and genomic repetitiveness of the loci predispose their susceptibility to epiallelic switching. The importance and predictive power of these genetic features were confirmed by analyses of common epialleles in natural Arabidopsis accessions, epigenetic recombinant inbred lines (epiRILs) and also verified in rice.

KW - Arabidopsis/genetics

KW - Arabidopsis Proteins/genetics

KW - DNA (Cytosine-5-)-Methyltransferases/genetics

KW - DNA Methylation

KW - DNA, Plant/chemistry

KW - Epigenesis, Genetic

KW - Gene Expression Regulation, Plant

KW - Mutation

U2 - 10.15252/embj.201695602

DO - 10.15252/embj.201695602

M3 - Article

C2 - 28069706

VL - 36

SP - 617

EP - 628

JO - The EMBO journal

JF - The EMBO journal

SN - 0261-4189

IS - 5

ER -