DNA damage emergency: cellular garbage disposal to the rescue?

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DNA damage emergency: cellular garbage disposal to the rescue? / Stone, Helen; Morris, Jo.

In: Oncogene, Vol. 33, 18.03.2013, p. 805-813.

Research output: Contribution to journalReview articlepeer-review

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@article{8a24ab3a54014f5bb305668731926a76,
title = "DNA damage emergency: cellular garbage disposal to the rescue?",
abstract = "The proteasome is a cellular machine found in the cytosol, nucleus and on chromatin that performs much of the proteolysis in eukaryotic cells. Recent reports show it is enriched at sites of double-stranded DNA breaks (DSBs) in mammalian cells. What is it doing there? This review will address three possibilities suggested by recent reports: in degrading proteins after their ubiquitination at and eviction from chromatin; as a deubiquitinase, specific to the antagonism of ubiquitin conjugates generated as part of the signalling of a DSB; and as a functional component of DNA repair mechanism itself. These findings add complexity to the proteasome as a potential therapeutic target in cancer treatment.",
keywords = "DNA damage, cellular",
author = "Helen Stone and Jo Morris",
year = "2013",
month = mar,
day = "18",
doi = "10.1038/onc.2013.60",
language = "English",
volume = "33",
pages = "805--813",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - DNA damage emergency: cellular garbage disposal to the rescue?

AU - Stone, Helen

AU - Morris, Jo

PY - 2013/3/18

Y1 - 2013/3/18

N2 - The proteasome is a cellular machine found in the cytosol, nucleus and on chromatin that performs much of the proteolysis in eukaryotic cells. Recent reports show it is enriched at sites of double-stranded DNA breaks (DSBs) in mammalian cells. What is it doing there? This review will address three possibilities suggested by recent reports: in degrading proteins after their ubiquitination at and eviction from chromatin; as a deubiquitinase, specific to the antagonism of ubiquitin conjugates generated as part of the signalling of a DSB; and as a functional component of DNA repair mechanism itself. These findings add complexity to the proteasome as a potential therapeutic target in cancer treatment.

AB - The proteasome is a cellular machine found in the cytosol, nucleus and on chromatin that performs much of the proteolysis in eukaryotic cells. Recent reports show it is enriched at sites of double-stranded DNA breaks (DSBs) in mammalian cells. What is it doing there? This review will address three possibilities suggested by recent reports: in degrading proteins after their ubiquitination at and eviction from chromatin; as a deubiquitinase, specific to the antagonism of ubiquitin conjugates generated as part of the signalling of a DSB; and as a functional component of DNA repair mechanism itself. These findings add complexity to the proteasome as a potential therapeutic target in cancer treatment.

KW - DNA damage

KW - cellular

U2 - 10.1038/onc.2013.60

DO - 10.1038/onc.2013.60

M3 - Review article

VL - 33

SP - 805

EP - 813

JO - Oncogene

JF - Oncogene

SN - 0950-9232

ER -