Diverse Profiles of Anxiety Related Disorders in Fragile X, Cornelia de Lange and Rubinstein–Taybi Syndromes
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Diverse Profiles of Anxiety Related Disorders in Fragile X, Cornelia de Lange and Rubinstein–Taybi Syndromes. / Crawford, Hayley; Waite, Jane; Oliver, Chris.
In: Journal of Autism and Developmental Disorders, Vol. 47, No. 12, 12.2017, p. 3728–3740.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Diverse Profiles of Anxiety Related Disorders in Fragile X, Cornelia de Lange and Rubinstein–Taybi Syndromes
AU - Crawford, Hayley
AU - Waite, Jane
AU - Oliver, Chris
PY - 2017/12
Y1 - 2017/12
N2 - Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous aetiology. In this study, we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein–Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and (a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive–compulsive subscales (b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive–compulsive subscales, and (c) participants with RTS on panic/agoraphobia and obsessive–compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.
AB - Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous aetiology. In this study, we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein–Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and (a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive–compulsive subscales (b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive–compulsive subscales, and (c) participants with RTS on panic/agoraphobia and obsessive–compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.
KW - Anxiety
KW - Cornelia de Lange syndrome
KW - Fragile X syndrome
KW - Genetic syndromes
KW - Intellectual disability
KW - Rubinstein–Taybi syndrome
UR - http://www.scopus.com/inward/record.url?scp=85011258315&partnerID=8YFLogxK
U2 - 10.1007/s10803-016-3015-y
DO - 10.1007/s10803-016-3015-y
M3 - Article
AN - SCOPUS:85011258315
VL - 47
SP - 3728
EP - 3740
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 12
ER -