Diverse Profiles of Anxiety Related Disorders in Fragile X, Cornelia de Lange and Rubinstein–Taybi Syndromes

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Colleges, School and Institutes

External organisations

  • Centre for Research in Psychology
  • Coventry University
  • University of Birmingham


Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous aetiology. In this study, we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein–Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and (a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive–compulsive subscales (b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive–compulsive subscales, and (c) participants with RTS on panic/agoraphobia and obsessive–compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.


Original languageEnglish
Pages (from-to)3728–3740
Number of pages13
JournalJournal of Autism and Developmental Disorders
Issue number12
Early online date31 Jan 2017
Publication statusPublished - Dec 2017


  • Anxiety, Cornelia de Lange syndrome, Fragile X syndrome, Genetic syndromes, Intellectual disability, Rubinstein–Taybi syndrome