Diverse Profiles of Anxiety Related Disorders in Fragile X, Cornelia de Lange and Rubinstein–Taybi Syndromes

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Colleges, School and Institutes

External organisations

  • Centre for Research in Psychology
  • Coventry University
  • School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.


Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous aetiology. In this study, we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein–Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and (a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive–compulsive subscales (b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive–compulsive subscales, and (c) participants with RTS on panic/agoraphobia and obsessive–compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.


Original languageEnglish
Pages (from-to)3728–3740
Number of pages13
JournalJournal of Autism and Developmental Disorders
Issue number12
Early online date31 Jan 2017
Publication statusPublished - Dec 2017


  • Anxiety, Cornelia de Lange syndrome, Fragile X syndrome, Genetic syndromes, Intellectual disability, Rubinstein–Taybi syndrome