Distribution of GABA_B(1a), GABA_B(1b) and GABA_B2 receptor protein in cerebral cortex and thalamus of adult rats

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The distribution of GABA(B) receptor subunits GABA(B(1a)), GABA(B(1b)) and GABA(B2), has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABA(B(1a)) and GABA(B(1b)) subunits co-localized with GABA(B2) in the cortex, where afferent thalamic GABAergic axons project to pyramidal neurones. The expression patterns of GABA(B(1a)), GABA(B(1b)) and GABA(B2) were similar throughout the thalamus. The data suggest that the GABA(B(1b)) subunit might be the presynaptic isoform in the thalamo-cortical pathway with the GABA(B(1a)) subunit possibly present at postsynaptic sites on cell bodies. This contrasts with our previous data, obtained in cerebellum and spinal cord which indicate opposite locations. Thus, it seems unlikely that functional role along with cellular location can be assigned in a general manner to specific GABAB receptor subunit splice variants. NeuroReport 12:591-595 (C) 2001 Lippincott Williams & Wilkins.

Details

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalNeuroReport
Volume12
Issue number3
Publication statusPublished - 1 Mar 2001

Keywords

  • thalamus, somatosensory system, cortex, heteromeric GABA(B)