Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks

Research output: Contribution to journalArticlepeer-review

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Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks. / Herz, Damian M; Tan, Huiling; Brittain, John-stuart; Fischer, Petra; Cheeran, Binith; Green, Alexander L; Fitzgerald, James; Aziz, Tipu Z; Ashkan, Keyoumars; Little, Simon; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Bogacz, Rafal; Brown, Peter.

In: eLife, Vol. 6, e21481, 31.01.2017.

Research output: Contribution to journalArticlepeer-review

Harvard

Herz, DM, Tan, H, Brittain, J, Fischer, P, Cheeran, B, Green, AL, Fitzgerald, J, Aziz, TZ, Ashkan, K, Little, S, Foltynie, T, Limousin, P, Zrinzo, L, Bogacz, R & Brown, P 2017, 'Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks', eLife, vol. 6, e21481. https://doi.org/10.7554/eLife.21481

APA

Herz, D. M., Tan, H., Brittain, J., Fischer, P., Cheeran, B., Green, A. L., Fitzgerald, J., Aziz, T. Z., Ashkan, K., Little, S., Foltynie, T., Limousin, P., Zrinzo, L., Bogacz, R., & Brown, P. (2017). Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks. eLife, 6, [e21481]. https://doi.org/10.7554/eLife.21481

Vancouver

Author

Herz, Damian M ; Tan, Huiling ; Brittain, John-stuart ; Fischer, Petra ; Cheeran, Binith ; Green, Alexander L ; Fitzgerald, James ; Aziz, Tipu Z ; Ashkan, Keyoumars ; Little, Simon ; Foltynie, Thomas ; Limousin, Patricia ; Zrinzo, Ludvic ; Bogacz, Rafal ; Brown, Peter. / Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks. In: eLife. 2017 ; Vol. 6.

Bibtex

@article{e36926364814493093651a692b3363ad,
title = "Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks",
abstract = "Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson{\textquoteright}s disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2–8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13–30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.",
author = "Herz, {Damian M} and Huiling Tan and John-stuart Brittain and Petra Fischer and Binith Cheeran and Green, {Alexander L} and James Fitzgerald and Aziz, {Tipu Z} and Keyoumars Ashkan and Simon Little and Thomas Foltynie and Patricia Limousin and Ludvic Zrinzo and Rafal Bogacz and Peter Brown",
year = "2017",
month = jan,
day = "31",
doi = "10.7554/eLife.21481",
language = "English",
volume = "6",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks

AU - Herz, Damian M

AU - Tan, Huiling

AU - Brittain, John-stuart

AU - Fischer, Petra

AU - Cheeran, Binith

AU - Green, Alexander L

AU - Fitzgerald, James

AU - Aziz, Tipu Z

AU - Ashkan, Keyoumars

AU - Little, Simon

AU - Foltynie, Thomas

AU - Limousin, Patricia

AU - Zrinzo, Ludvic

AU - Bogacz, Rafal

AU - Brown, Peter

PY - 2017/1/31

Y1 - 2017/1/31

N2 - Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson’s disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2–8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13–30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.

AB - Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson’s disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2–8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13–30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.

U2 - 10.7554/eLife.21481

DO - 10.7554/eLife.21481

M3 - Article

VL - 6

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e21481

ER -