Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks

Research output: Contribution to journalArticle

Authors

  • Damian M Herz
  • Huiling Tan
  • Petra Fischer
  • Binith Cheeran
  • Alexander L Green
  • James Fitzgerald
  • Tipu Z Aziz
  • Keyoumars Ashkan
  • Simon Little
  • Thomas Foltynie
  • Patricia Limousin
  • Ludvic Zrinzo
  • Rafal Bogacz
  • Peter Brown

Colleges, School and Institutes

External organisations

  • Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
  • Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom
  • Department of Neurosurgery, King’s College Hospital, London, United Kingdom
  • University College London

Abstract

Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson’s disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2–8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13–30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.

Details

Original languageEnglish
Article numbere21481
JournalElife
Volume6
Publication statusPublished - 31 Jan 2017