Dissociation of cross-sectional trajectories for verbal and visuo-spatial working memory development in Rubinstein-Taybi syndrome

Research output: Contribution to journalArticle

Colleges, School and Institutes

External organisations

  • Gloucestershire Hospitals NHS Foundation Trust

Abstract

Working memory (WM) impairments might amplify behavioural difference in genetic syndromes. Murine models of Rubinstein–Taybi syndrome (RTS) evidence memory impairments but there is limited research on memory in RTS. Individuals with RTS and typically developing children completed WM tasks, with participants with RTS completing an IQ assessment and parents/carers completing the Vineland Adaptive Behavior Scales. A cross-sectional trajectory analysis was conducted. There were significant WM span deficits in RTS relative to mental age. Verbal WM span was positively associated with mental age; however, this was not observed for visuo-spatial span. There is a dissociation between WM domains in RTS. Individuals may have difficulties with tasks relying on WM span, above difficulties predicted by overall ability.

Details

Original languageEnglish
Pages (from-to)2064-2071
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume46
Issue number6
Early online date24 Mar 2016
Publication statusPublished - Jun 2016

Keywords

  • Dissociation, Rubinstein–Taybi syndrome, Short-term memory, Typically developing children, Working memory