Dissecting Clonal Heterogeneity in AML
Research output: Contribution to journal › Article
Authors
Colleges, School and Institutes
External organisations
- University of Groningen, University Medical Center Groningen, Department of Cell Biology, Groningen, Groningen, Netherlands ; b.n.g.giepmans@umcg.nl.
Abstract
Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.
Details
Original language | English |
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Pages (from-to) | 782-784 |
Number of pages | 3 |
Journal | Cancer Cell |
Volume | 38 |
Issue number | 6 |
Publication status | Published - 14 Dec 2020 |