Dissecting Clonal Heterogeneity in AML

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • University of Groningen, University Medical Center Groningen, Department of Cell Biology, Groningen, Groningen, Netherlands ; b.n.g.giepmans@umcg.nl.

Abstract

Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.

Details

Original languageEnglish
Pages (from-to)782-784
Number of pages3
JournalCancer Cell
Volume38
Issue number6
Publication statusPublished - 14 Dec 2020