Disease activity and patient reported outcome measures in Sjögren's - what are the best tools to evaluate?
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
In primary SS (pSS), clinical features in SS can be divided into two facets: the patient perceived manifestations such as dryness, pain and fatigue, and the systemic manifestations. In the past decades, with efforts made by an international collaboration, consensual clinical indexes were developed for assessing both facets: one patient reported outcome, the EULAR SS Patients Reported Index (ESSPRI), and one activity index for systemic manifestations, the EULAR SS Disease Activity Index (ESSDAI). In addition, objective measures were developed to quantify the importance and consequence of ocular and oral dryness, few being specific of pSS. Work is ongoing to develop indexes combining all these approaches. Recent changes in the assessment of pSS patients, and the emergence of new targeted therapies, have put a greater emphasis on the design of clinical trials in pSS, and led for the first time to a positive randomized clinical trial.
|Number of pages||12|
|Journal||Rheumatology (Oxford, England)|
|Early online date||24 Jun 2019|
|Publication status||E-pub ahead of print - 24 Jun 2019|
- primary Sjögren's syndrome, ESSDAI, ESSPRI, outcome measure, patient reported outcome, clinical endpoints, clinical evaluation