Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation

Mostapha Ariane; Mohamed Hatem Allouche; Marco Bussone; Fausto Giacosa; Frédéric Bernard; Mostafa Barigou; Alessio Alexiadis

doi:10.1371/journal.pone.0174795

Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation

Mostapha Ariane, Mohamed Hatem Allouche, Marco Bussone, Fausto Giacosa, Frédéric Bernard, Mostafa Barigou, Alessio Alexiadis

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

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Abstract

We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves.

Original language	English
Article number	e0174795
Journal	PLoS ONE
Volume	12
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0174795
Publication status	Published - 6 Apr 2017

ASJC Scopus subject areas

General Medicine
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1371/journal.pone.0174795Licence: Creative Commons: Attribution (CC BY)

ArianeM2017Discrete
Ariane M, Allouche MH, Bussone M, Giacosa F, Bernard F, Barigou M, et al. (2017) Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation. PLoS ONE 12(4): e0174795. https://doi.org/10.1371/journal.pone.0174795
Final published version, 3.02 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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AU - Bernard, Frédéric

AU - Barigou, Mostafa

AU - Alexiadis, Alessio

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Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation

Abstract

ASJC Scopus subject areas

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