Directional local field potentials: a tool to optimize deep brain stimulation

Gerd Tinkhauser; Alek Pogosyan; Ines Debove; Andreas Nowacki; Syed Ahmar Shah; Kathleen Seidel; Huiling Tan; John-Stuart Brittain; Katrin Petermann; Lazzaro di Biase; Markus Oertel; Claudio Pollo; Peter Brown; Michael Schuepbach

doi:10.1002/mds.27215

Directional local field potentials: a tool to optimize deep brain stimulation

Gerd Tinkhauser, Alek Pogosyan, Ines Debove, Andreas Nowacki, Syed Ahmar Shah, Kathleen Seidel, Huiling Tan, John-Stuart Brittain, Katrin Petermann, Lazzaro di Biase, Markus Oertel, Claudio Pollo, Peter Brown, Michael Schuepbach

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Abstract

Introduction: Although recently introduced directional deep brain stimulation leads provide control of the stimulation field, programing is time consuming. Here we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with Parkinson’s disease. Methods: Intraoperative local field potentials were recorded from directional contacts in the subthalamic nucleus of 12 patients and beta activity compared with the results of the clinical contact review performed after 4-7 months. Results: Normalized beta activity was positively correlated with the contact’s clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92 % and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional deep brain stimulation.

Original language	English
Pages (from-to)	159–164
Number of pages	15
Journal	Movement Disorders
Volume	33
Issue number	1
Early online date	18 Nov 2017
DOIs	https://doi.org/10.1002/mds.27215
Publication status	Published - Jan 2018

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Tinkhauser, G., Pogosyan, A., Debove, I., Nowacki, A., Shah, S. A., Seidel, K., Tan, H., Brittain, J-S., Petermann, K., di Biase, L., Oertel, M., Pollo, C., Brown, P., & Schuepbach, M. (2018). Directional local field potentials: a tool to optimize deep brain stimulation. Movement Disorders, 33(1), 159–164. Advance online publication. https://doi.org/10.1002/mds.27215

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title = "Directional local field potentials: a tool to optimize deep brain stimulation",

abstract = "Introduction: Although recently introduced directional deep brain stimulation leads provide control of the stimulation field, programing is time consuming. Here we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with Parkinson{\textquoteright}s disease. Methods: Intraoperative local field potentials were recorded from directional contacts in the subthalamic nucleus of 12 patients and beta activity compared with the results of the clinical contact review performed after 4-7 months. Results: Normalized beta activity was positively correlated with the contact{\textquoteright}s clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92 % and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional deep brain stimulation.",

author = "Gerd Tinkhauser and Alek Pogosyan and Ines Debove and Andreas Nowacki and Shah, {Syed Ahmar} and Kathleen Seidel and Huiling Tan and John-Stuart Brittain and Katrin Petermann and {di Biase}, Lazzaro and Markus Oertel and Claudio Pollo and Peter Brown and Michael Schuepbach",

year = "2018",

month = jan,

doi = "10.1002/mds.27215",

language = "English",

volume = "33",

pages = "159–164",

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T1 - Directional local field potentials

T2 - a tool to optimize deep brain stimulation

AU - Tinkhauser, Gerd

AU - Pogosyan, Alek

AU - Debove, Ines

AU - Nowacki, Andreas

AU - Shah, Syed Ahmar

AU - Seidel, Kathleen

AU - Tan, Huiling

AU - Brittain, John-Stuart

AU - Petermann, Katrin

AU - di Biase, Lazzaro

AU - Oertel, Markus

AU - Pollo, Claudio

AU - Brown, Peter

AU - Schuepbach, Michael

PY - 2018/1

Y1 - 2018/1

N2 - Introduction: Although recently introduced directional deep brain stimulation leads provide control of the stimulation field, programing is time consuming. Here we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with Parkinson’s disease. Methods: Intraoperative local field potentials were recorded from directional contacts in the subthalamic nucleus of 12 patients and beta activity compared with the results of the clinical contact review performed after 4-7 months. Results: Normalized beta activity was positively correlated with the contact’s clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92 % and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional deep brain stimulation.

AB - Introduction: Although recently introduced directional deep brain stimulation leads provide control of the stimulation field, programing is time consuming. Here we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with Parkinson’s disease. Methods: Intraoperative local field potentials were recorded from directional contacts in the subthalamic nucleus of 12 patients and beta activity compared with the results of the clinical contact review performed after 4-7 months. Results: Normalized beta activity was positively correlated with the contact’s clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92 % and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional deep brain stimulation.

U2 - 10.1002/mds.27215

DO - 10.1002/mds.27215

M3 - Article

SN - 0885-3185

VL - 33

SP - 159

EP - 164

JO - Movement Disorders

JF - Movement Disorders

IS - 1

ER -

Directional local field potentials: a tool to optimize deep brain stimulation

Abstract

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