Directional local field potentials: a tool to optimize deep brain stimulation

Research output: Contribution to journalArticlepeer-review

Authors

  • Gerd Tinkhauser
  • Alek Pogosyan
  • Ines Debove
  • Andreas Nowacki
  • Syed Ahmar Shah
  • Kathleen Seidel
  • Huiling Tan
  • Katrin Petermann
  • Lazzaro di Biase
  • Markus Oertel
  • Claudio Pollo
  • Peter Brown
  • Michael Schuepbach

Colleges, School and Institutes

Abstract

Introduction: Although recently introduced directional deep brain stimulation leads provide control of the stimulation field, programing is time consuming. Here we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with Parkinson’s disease. Methods: Intraoperative local field potentials were recorded from directional contacts in the subthalamic nucleus of 12 patients and beta activity compared with the results of the clinical contact review performed after 4-7 months. Results: Normalized beta activity was positively correlated with the contact’s clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92 % and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional deep brain stimulation.

Details

Original languageEnglish
Pages (from-to)159–164
Number of pages15
JournalMovement Disorders
Volume33
Issue number1
Early online date18 Nov 2017
Publication statusPublished - Jan 2018