Directional local field potentials: a tool to optimize deep brain stimulation
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Introduction: Although recently introduced directional deep brain stimulation leads provide control of the stimulation field, programing is time consuming. Here we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with Parkinson’s disease. Methods: Intraoperative local field potentials were recorded from directional contacts in the subthalamic nucleus of 12 patients and beta activity compared with the results of the clinical contact review performed after 4-7 months. Results: Normalized beta activity was positively correlated with the contact’s clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92 % and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional deep brain stimulation.
|Number of pages||15|
|Early online date||18 Nov 2017|
|Publication status||Published - Jan 2018|