Direct observation of reversible biomolecule switching controlled by electrical stimulus

Alice Pranzetti; Matthew Davis; Chun-Ling Yeung; Jon A. Preece; Patrick Koelsch; Paula M. Mendes

doi:10.1002/admi.201400026

Direct observation of reversible biomolecule switching controlled by electrical stimulus

Alice Pranzetti, Matthew Davis, Chun-Ling Yeung, Jon A. Preece, Patrick Koelsch, Paula M. Mendes

Research output: Contribution to journal › Article › peer-review

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Abstract

In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.

Original language	English
Article number	1400026
Journal	Advanced Materials Interfaces
Volume	1
Issue number	5
Early online date	4 Apr 2014
DOIs	https://doi.org/10.1002/admi.201400026
Publication status	Published - 22 Aug 2014

Keywords

switchable surfaces
self-assembled monolayers
sum frequency generation
electrochemistry

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10.1002/admi.201400026

Pranzetti_Direct_observation_reversible_biomolecule_switching_Advanced_Materials_Interfaces_2014
Eligibility for repository : checked 10/10/2014
Final published version, 811 KBLicence: Creative Commons: Attribution (CC BY)

http://doi.wiley.com/10.1002/admi.201400026

Switchable Nanostructured Surfaces as a Sophisticated Tool for Cell Biologists
Mendes, P., Kirkman-Brown, J. & Publicover, S.
THE WELLCOME TRUST
10/01/11 → 9/05/14
Project: Research

Cite this

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title = "Direct observation of reversible biomolecule switching controlled by electrical stimulus",

abstract = "In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.",

keywords = "switchable surfaces, self-assembled monolayers, sum frequency generation, electrochemistry",

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AU - Pranzetti, Alice

AU - Davis, Matthew

AU - Yeung, Chun-Ling

AU - Preece, Jon A.

AU - Koelsch, Patrick

AU - Mendes, Paula M.

PY - 2014/8/22

Y1 - 2014/8/22

N2 - In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.

AB - In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.

KW - switchable surfaces

KW - self-assembled monolayers

KW - sum frequency generation

KW - electrochemistry

U2 - 10.1002/admi.201400026

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M3 - Article

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VL - 1

JO - Advanced Materials Interfaces

JF - Advanced Materials Interfaces

IS - 5

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ER -

Direct observation of reversible biomolecule switching controlled by electrical stimulus

Abstract

Keywords

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Switchable Nanostructured Surfaces as a Sophisticated Tool for Cell Biologists

Cite this