Direct electrophysiological evidence for prefrontal control of hippocampal processing during voluntary forgetting

Research output: Contribution to journalArticlepeer-review

Authors

  • Carina R. Oehrn
  • Juergen Fell
  • Conrad Baumann
  • Timm Rosburg
  • Eva Ludowig
  • Henrik Kessler
  • Nikolai Axmacher

Abstract

Forgetting does not necessarily reflect failure to encode information, but can to some extent also be voluntarily controlled. Previous studies have suggested that voluntary forgetting relies on active inhibition of encoding processes in the hippocampus by the dorsolateral prefrontal cortex (DLPFC) [1-4]. During attentional and sensorimotor processing, enhanced DLPFC theta power alongside increased alpha/beta oscillations are a neural signature of an inhibitory top-down mechanism, with theta oscillations reflecting prefrontal control and alpha/beta oscillations occurring in areas targeted by inhibition [5-12]. Here, we used intracranial EEG recordings in presurgical epilepsy patients implanted in DLPFC (n=13) and hippocampus (n=15) during an item-method directed forgetting paradigm. We found that voluntary forgetting is associated with increased neural oscillations in the low theta band (3-5Hz) in DLPFC and in a broad theta/alpha/beta (6-18Hz) frequency range in hippocampus. Combining time-lagged correlation analysis, phase synchronization and Granger causality in 6 patients with electrodes in both DLPFC and hippocampus, we obtained converging evidence for a top-down control of hippocampal activity by the DLPFC. Together, our results provide strong support for a model in which voluntary forgetting relies on enhanced control of the hippocampus by the DLPFC.

Details

Original languageEnglish
Pages (from-to)3016-3022.e4
Number of pages12
JournalCurrent Biology
Volume28
Issue number18
Early online date6 Sep 2018
Publication statusPublished - 24 Sep 2018

Keywords

  • directed forgetting, intracranial, iEEG, oscillations, prefrontal cortex, DLPFC, hippocampus, theta, alpha, beta