Differential oscillatory electroencephalogram between attention-deficit/hyperactivity disorder subtypes and typically developing adolescents

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Differential oscillatory electroencephalogram between attention-deficit/hyperactivity disorder subtypes and typically developing adolescents. / Mazaheri, Ali; Fassbender, Catherine ; Coffey-Corina, Sharon ; A. Hartanto, Tadeus ; B. Schweitzer, Julie ; Mangun, Ron.

In: Biological Psychiatry, Vol. 76, No. 5, 01.09.2014, p. 422–429.

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Mazaheri, Ali ; Fassbender, Catherine ; Coffey-Corina, Sharon ; A. Hartanto, Tadeus ; B. Schweitzer, Julie ; Mangun, Ron. / Differential oscillatory electroencephalogram between attention-deficit/hyperactivity disorder subtypes and typically developing adolescents. In: Biological Psychiatry. 2014 ; Vol. 76, No. 5. pp. 422–429.

Bibtex

@article{3289a384c455479681869cb86a6a131c,
title = "Differential oscillatory electroencephalogram between attention-deficit/hyperactivity disorder subtypes and typically developing adolescents",
abstract = "BackgroundA neurobiological-based classification of attention-deficit/hyperactivity disorder (ADHD) subtypes has thus far remained elusive. The aim of this study was to use oscillatory changes in the electroencephalogram (EEG) related to informative cue processing, motor preparation, and top-down control to investigate neurophysiological differences between typically developing (TD) adolescents, and those diagnosed with predominantly inattentive (IA) or combined (CB) (associated with symptoms of inattention as well as impulsivity/hyperactivity) subtypes of ADHD.MethodsThe EEG was recorded from 57 rigorously screened adolescents (12 to17 years of age; 23 TD, 17 IA, and 17 CB), while they performed a cued flanker task. We examined the oscillatory changes in theta (3–5 Hz), alpha (8–12 Hz), and beta (22–25 Hz) EEG bands after cues that informed participants with which hand they would subsequently be required to respond.ResultsRelative to TD adolescents, the IA group showed significantly less postcue alpha suppression, suggesting diminished processing of the cue in the visual cortex, whereas the CB group showed significantly less beta suppression at the electrode contralateral to the cued response hand, suggesting poor motor planning. Finally, both ADHD subtypes showed weak functional connectivity between frontal theta and posterior alpha, suggesting common top-down control impairment.ConclusionsWe found both distinct and common task-related neurophysiological impairments in ADHD subtypes. Our results suggest that task-induced changes in EEG oscillations provide an objective measure, which in conjunction with other sources of information might help distinguish between ADHD subtypes and therefore aid in diagnoses and evaluation of treatment.",
keywords = "response preparation, top-down control, Attention-deficit/hyperactivity disorder, connectivity, cue-processing, EEG oscillations",
author = "Ali Mazaheri and Catherine Fassbender and Sharon Coffey-Corina and {A. Hartanto}, Tadeus and {B. Schweitzer}, Julie and Ron Mangun",
year = "2014",
month = sep,
day = "1",
doi = "10.1016/j.biopsych.2013.08.023",
language = "English",
volume = "76",
pages = " 422–429",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Differential oscillatory electroencephalogram between attention-deficit/hyperactivity disorder subtypes and typically developing adolescents

AU - Mazaheri, Ali

AU - Fassbender, Catherine

AU - Coffey-Corina, Sharon

AU - A. Hartanto, Tadeus

AU - B. Schweitzer, Julie

AU - Mangun, Ron

PY - 2014/9/1

Y1 - 2014/9/1

N2 - BackgroundA neurobiological-based classification of attention-deficit/hyperactivity disorder (ADHD) subtypes has thus far remained elusive. The aim of this study was to use oscillatory changes in the electroencephalogram (EEG) related to informative cue processing, motor preparation, and top-down control to investigate neurophysiological differences between typically developing (TD) adolescents, and those diagnosed with predominantly inattentive (IA) or combined (CB) (associated with symptoms of inattention as well as impulsivity/hyperactivity) subtypes of ADHD.MethodsThe EEG was recorded from 57 rigorously screened adolescents (12 to17 years of age; 23 TD, 17 IA, and 17 CB), while they performed a cued flanker task. We examined the oscillatory changes in theta (3–5 Hz), alpha (8–12 Hz), and beta (22–25 Hz) EEG bands after cues that informed participants with which hand they would subsequently be required to respond.ResultsRelative to TD adolescents, the IA group showed significantly less postcue alpha suppression, suggesting diminished processing of the cue in the visual cortex, whereas the CB group showed significantly less beta suppression at the electrode contralateral to the cued response hand, suggesting poor motor planning. Finally, both ADHD subtypes showed weak functional connectivity between frontal theta and posterior alpha, suggesting common top-down control impairment.ConclusionsWe found both distinct and common task-related neurophysiological impairments in ADHD subtypes. Our results suggest that task-induced changes in EEG oscillations provide an objective measure, which in conjunction with other sources of information might help distinguish between ADHD subtypes and therefore aid in diagnoses and evaluation of treatment.

AB - BackgroundA neurobiological-based classification of attention-deficit/hyperactivity disorder (ADHD) subtypes has thus far remained elusive. The aim of this study was to use oscillatory changes in the electroencephalogram (EEG) related to informative cue processing, motor preparation, and top-down control to investigate neurophysiological differences between typically developing (TD) adolescents, and those diagnosed with predominantly inattentive (IA) or combined (CB) (associated with symptoms of inattention as well as impulsivity/hyperactivity) subtypes of ADHD.MethodsThe EEG was recorded from 57 rigorously screened adolescents (12 to17 years of age; 23 TD, 17 IA, and 17 CB), while they performed a cued flanker task. We examined the oscillatory changes in theta (3–5 Hz), alpha (8–12 Hz), and beta (22–25 Hz) EEG bands after cues that informed participants with which hand they would subsequently be required to respond.ResultsRelative to TD adolescents, the IA group showed significantly less postcue alpha suppression, suggesting diminished processing of the cue in the visual cortex, whereas the CB group showed significantly less beta suppression at the electrode contralateral to the cued response hand, suggesting poor motor planning. Finally, both ADHD subtypes showed weak functional connectivity between frontal theta and posterior alpha, suggesting common top-down control impairment.ConclusionsWe found both distinct and common task-related neurophysiological impairments in ADHD subtypes. Our results suggest that task-induced changes in EEG oscillations provide an objective measure, which in conjunction with other sources of information might help distinguish between ADHD subtypes and therefore aid in diagnoses and evaluation of treatment.

KW - response preparation

KW - top-down control

KW - Attention-deficit/hyperactivity disorder

KW - connectivity

KW - cue-processing

KW - EEG oscillations

U2 - 10.1016/j.biopsych.2013.08.023

DO - 10.1016/j.biopsych.2013.08.023

M3 - Article

VL - 76

SP - 422

EP - 429

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 5

ER -