Differential expression of potential biomarkers of oral squamous cell carcinoma development

Paola Fernandes Pansini; Isabella Bittencourt do Valle; Thabata Coeli Dias Damasceno; Priscila Marinho de Abreu; Anna Clara Gregório Có; Rossana Verónica Mendoza López; Jeferson Lenzi; Ricardo Mai Rocha; Evandro Duccini Souza; Maria Paula Curado; Hisham Mehanna; Paul Nankivell; José Roberto Vasconcelos de Podestá; Sandra Ventorin von Zeidler

doi:10.1007/s12105-021-01322-8

Differential expression of potential biomarkers of oral squamous cell carcinoma development

Paola Fernandes Pansini, Isabella Bittencourt do Valle, Thabata Coeli Dias Damasceno, Priscila Marinho de Abreu, Anna Clara Gregório Có, Rossana Verónica Mendoza López, Jeferson Lenzi, Ricardo Mai Rocha, Evandro Duccini Souza, Maria Paula Curado, Hisham Mehanna, Paul Nankivell, José Roberto Vasconcelos de Podestá, Sandra Ventorin von Zeidler

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Abstract

To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0.001), PLK1 (p = 0.001), and p63 (p < 0.001) in parallel to reduced immunostaining of p40 (p < 0.001) and BCL2 (p = 0.029) was observed among the tissue segments analyzed. Our study revealed that survivin, PLK1, p63, p40 and BCL2 play a role in oral tumorigenesis and represent promising biomarkers able to recognize mesenchymal phenotype induction in the transition from nonmalignant cells to tumor cells. These results reveals critical interaction between survivin, PLK1, p63, p40 promising proteins during invasive carcinoma development.

Original language	English
Pages (from-to)	1127-1136
Journal	Head and Neck Pathology
Volume	15
Issue number	4
Early online date	11 Apr 2021
DOIs	https://doi.org/10.1007/s12105-021-01322-8
Publication status	E-pub ahead of print - 11 Apr 2021

Bibliographical note

Funding Information:
The authors would like to thank the Head and Neck Division teams of the Santa Rita de Cássia Hospital, Cassiano Antônio Moraes University Hospital, and University Hospitals Coventry and Warwickshire NHS Trust. This study was financed by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001 and FAPES/CNPq/Decit-SCTIE-MS/SESA – PPSUS, Espírito Santo (Protocol number 83139940/2018).

Keywords

Biomarkers
Dysplasia
Immunohistochemistry
Oral cancer
Progression
Tumor

ASJC Scopus subject areas

Pathology and Forensic Medicine
Otorhinolaryngology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12105-021-01322-8

PansiniPF2021Differential
This is a post-peer-review, pre-copyedit version of an article published in Head and Neck Pathology. The final authenticated version is available online at: https://doi.org/10.1007/s12105-021-01322-8
Accepted author manuscript, 193 KBLicence: None: All rights reserved

Cite this

Pansini, P. F., do Valle, I. B., Damasceno, T. C. D., de Abreu, P. M., Có, A. C. G., López, R. V. M., Lenzi, J., Rocha, R. M., Souza, E. D., Curado, M. P., Mehanna, H., Nankivell, P., de Podestá, J. R. V., & von Zeidler, S. V. (2021). Differential expression of potential biomarkers of oral squamous cell carcinoma development. Head and Neck Pathology, 15(4), 1127-1136. Advance online publication. https://doi.org/10.1007/s12105-021-01322-8

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title = "Differential expression of potential biomarkers of oral squamous cell carcinoma development",

abstract = "To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0.001), PLK1 (p = 0.001), and p63 (p < 0.001) in parallel to reduced immunostaining of p40 (p < 0.001) and BCL2 (p = 0.029) was observed among the tissue segments analyzed. Our study revealed that survivin, PLK1, p63, p40 and BCL2 play a role in oral tumorigenesis and represent promising biomarkers able to recognize mesenchymal phenotype induction in the transition from nonmalignant cells to tumor cells. These results reveals critical interaction between survivin, PLK1, p63, p40 promising proteins during invasive carcinoma development.",

keywords = "Biomarkers, Dysplasia, Immunohistochemistry, Oral cancer, Progression, Tumor",

author = "Pansini, {Paola Fernandes} and {do Valle}, {Isabella Bittencourt} and Damasceno, {Thabata Coeli Dias} and {de Abreu}, {Priscila Marinho} and C{\'o}, {Anna Clara Greg{\'o}rio} and L{\'o}pez, {Rossana Ver{\'o}nica Mendoza} and Jeferson Lenzi and Rocha, {Ricardo Mai} and Souza, {Evandro Duccini} and Curado, {Maria Paula} and Hisham Mehanna and Paul Nankivell and {de Podest{\'a}}, {Jos{\'e} Roberto Vasconcelos} and {von Zeidler}, {Sandra Ventorin}",

note = "Funding Information: The authors would like to thank the Head and Neck Division teams of the Santa Rita de C{\'a}ssia Hospital, Cassiano Ant{\^o}nio Moraes University Hospital, and University Hospitals Coventry and Warwickshire NHS Trust. This study was financed by Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior – Brasil (CAPES) – Finance Code 001 and FAPES/CNPq/Decit-SCTIE-MS/SESA – PPSUS, Esp{\'i}rito Santo (Protocol number 83139940/2018).",

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doi = "10.1007/s12105-021-01322-8",

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Pansini, PF, do Valle, IB, Damasceno, TCD, de Abreu, PM, Có, ACG, López, RVM, Lenzi, J, Rocha, RM, Souza, ED, Curado, MP, Mehanna, H , Nankivell, P, de Podestá, JRV & von Zeidler, SV 2021, 'Differential expression of potential biomarkers of oral squamous cell carcinoma development', Head and Neck Pathology, vol. 15, no. 4, pp. 1127-1136. https://doi.org/10.1007/s12105-021-01322-8

TY - JOUR

T1 - Differential expression of potential biomarkers of oral squamous cell carcinoma development

AU - Pansini, Paola Fernandes

AU - do Valle, Isabella Bittencourt

AU - Damasceno, Thabata Coeli Dias

AU - de Abreu, Priscila Marinho

AU - Có, Anna Clara Gregório

AU - López, Rossana Verónica Mendoza

AU - Lenzi, Jeferson

AU - Rocha, Ricardo Mai

AU - Souza, Evandro Duccini

AU - Curado, Maria Paula

AU - Mehanna, Hisham

AU - Nankivell, Paul

AU - de Podestá, José Roberto Vasconcelos

AU - von Zeidler, Sandra Ventorin

N1 - Funding Information: The authors would like to thank the Head and Neck Division teams of the Santa Rita de Cássia Hospital, Cassiano Antônio Moraes University Hospital, and University Hospitals Coventry and Warwickshire NHS Trust. This study was financed by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001 and FAPES/CNPq/Decit-SCTIE-MS/SESA – PPSUS, Espírito Santo (Protocol number 83139940/2018).

PY - 2021/4/11

Y1 - 2021/4/11

N2 - To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0.001), PLK1 (p = 0.001), and p63 (p < 0.001) in parallel to reduced immunostaining of p40 (p < 0.001) and BCL2 (p = 0.029) was observed among the tissue segments analyzed. Our study revealed that survivin, PLK1, p63, p40 and BCL2 play a role in oral tumorigenesis and represent promising biomarkers able to recognize mesenchymal phenotype induction in the transition from nonmalignant cells to tumor cells. These results reveals critical interaction between survivin, PLK1, p63, p40 promising proteins during invasive carcinoma development.

AB - To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0.001), PLK1 (p = 0.001), and p63 (p < 0.001) in parallel to reduced immunostaining of p40 (p < 0.001) and BCL2 (p = 0.029) was observed among the tissue segments analyzed. Our study revealed that survivin, PLK1, p63, p40 and BCL2 play a role in oral tumorigenesis and represent promising biomarkers able to recognize mesenchymal phenotype induction in the transition from nonmalignant cells to tumor cells. These results reveals critical interaction between survivin, PLK1, p63, p40 promising proteins during invasive carcinoma development.

KW - Biomarkers

KW - Dysplasia

KW - Immunohistochemistry

KW - Oral cancer

KW - Progression

KW - Tumor

U2 - 10.1007/s12105-021-01322-8

DO - 10.1007/s12105-021-01322-8

M3 - Article

C2 - 33840043

SN - 1936-055X

VL - 15

SP - 1127

EP - 1136

JO - Head and Neck Pathology

JF - Head and Neck Pathology

IS - 4

ER -

Differential expression of potential biomarkers of oral squamous cell carcinoma development

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this