Diagnosis and management of migraine in ten steps: consensus statement

Research output: Contribution to journalReview articlepeer-review


  • Anna Eigenbrodt
  • Hakan Ashina
  • Sabrina Khan
  • Hans-Christoph Diener
  • Dimos Mitsikostas
  • Patricia Pozo-Rosich
  • Paolo Martelletti
  • Anne Ducros
  • Michel Lanteri-Minet
  • Mark Braschinsky
  • Margarita Sanchez Del Rio
  • Oved Daniel
  • Anur Ozge
  • Ayten Mammadbayli
  • Mihails Arons
  • Kirill Skorobogatykh
  • Vladmir Romanenko
  • Gisela Terwindt
  • Koen Paemeleire
  • Simona Sacco
  • Uwe Reuter
  • Christian Lampl
  • Henrik Winther Schytz
  • Zara Katsarava
  • Timothy Steiner
  • Messoud Ashina

Colleges, School and Institutes


Migraine is a disabling primary headache disorder that directly affects more than one billion people worldwide. Despite its widespread prevalence, migraine remains under-diagnosed and under-treated. To support clinical decision-making, we convened a European panel of experts to develop a ten-step approach to the diagnosis and management of migraine. Each step was established by expert consensus and supported by a review of current literature, and the Consensus Statement is endorsed by the European Headache Federation and the European Academy of Neurology. In this Consensus Statement, we introduce typical clinical features, diagnostic criteria and differential diagnoses of migraine. We then emphasize the value of patient centricity and patient education to ensure treatment adherence and satisfaction with care provision. Further, we outline best practices for acute and preventive treatment of migraine in various patient populations, including adults, children and adolescents, pregnant and breastfeeding women, and older people. In addition, we provide recommendations for evaluating treatment response and managing treatment failure. Lastly, we discuss the management of complications and comorbidities as well as the importance of planning long-term follow-up.


Original languageEnglish
JournalNature Reviews Neurology
Early online date18 Jun 2021
Publication statusE-pub ahead of print - 18 Jun 2021