Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial)
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Objectives: To determine whether preoperative dexamethasone reduces postoperative vomiting in patients undergoing elective bowel surgery and whether it is associated with other measurable benefits during recovery from surgery, including quicker return to oral diet and reduced length of stay.
Design: Pragmatic two arm parallel group randomised trial with blinded postoperative care and outcome assessment.
Setting: 45 UK hospitals.
Participants: 1350 patients aged 18 or over undergoing elective open or laparoscopic bowel surgery for malignant or benign pathology.
Interventions: Addition of a single dose of 8 mg intravenous dexamethasone at induction of anaesthesia compared with standard care.
Main outcome measures: Primary outcome: reported vomiting within 24 hours reported by patient or clinician. Secondary outcomes: vomiting with 72 and 120 hours reported by patient or clinician; use of antiemetics and postoperative nausea and vomiting at 24, 72, and 120 hours rated by patient; fatigue and quality of life at 120 hours or discharge and at 30 days; time to return to fluid and food intake; length of hospital stay; adverse events.
Results: 1350 participants were recruited and randomly allocated to additional dexamethasone (n=674) or standard care (n=676) at induction of anaesthesia. Vomiting within 24 hours of surgery occurred in 172 (25.5%) participants in the dexamethasone arm and 223 (33.0%) allocated standard care (number needed to treat (NNT) 13, 95% confidence interval 5 to 22; P=0.003). Additional postoperative antiemetics were given (on demand) to 265 (39.3%) participants allocated dexamethasone and 351 (51.9%) allocated standard care (NNT 8, 5 to 11; P<0.001). Reduction in on demand antiemetics remained up to 72 hours. There was no increase in complications.
Conclusions: Addition of a single dose of 8 mg intravenous dexamethasone at induction of anaesthesia significantly reduces both the incidence of postoperative nausea and vomiting at 24 hours and the need for rescue antiemetics for up to 72 hours in patients undergoing large and small bowel surgery, with no increase in adverse events.
Trial registration EudraCT (2010-022894-32) and ISRCTN (ISRCTN21973627).
|Publication status||Published - 18 Apr 2017|
- Adult, Aged, Aged, 80 and over, Antiemetics, Dexamethasone, Double-Blind Method, Eating, Female, Humans, Injections, Intravenous, Intestines, Length of Stay, Male, Middle Aged, Postoperative Nausea and Vomiting, Postoperative Period, Preanesthetic Medication, Recovery of Function, Treatment Outcome, Young Adult, Journal Article, Multicenter Study, Randomized Controlled Trial