Developmental changes in the differentiation capacity of hematopoietic stem cells

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Colleges, School and Institutes


Haematopoietic stem cells (HSCs) can be found in different locations of the developing vertebrate organism. Recent studies have detected functional changes in the haematopoietic system during ontogeny. Depending on the developmental stage, HSCs create different progeny, which express distinct marker genes. In addition, haematopoietic development is differentially affected by a variety of mutations. Here, Constanze Bonifer and colleagues discuss the existence of HSCs with specific differentiation capacities.


Original languageEnglish
Pages (from-to)236-241
JournalImmunology Today
Issue number5
Publication statusPublished - 1 May 1998


  • development changes, Hematopoietic Stem Cells