Developmental changes in the differentiation capacity of hematopoietic stem cells

Constanze Bonifer; N Faust; H Geiger; A Muller

doi:http://dx.doi.org/10.1016/S0167-5699(98)01259-6

Developmental changes in the differentiation capacity of hematopoietic stem cells

Constanze Bonifer, N Faust, H Geiger, A Muller

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Haematopoietic stem cells (HSCs) can be found in different locations of the developing vertebrate organism. Recent studies have detected functional changes in the haematopoietic system during ontogeny. Depending on the developmental stage, HSCs create different progeny, which express distinct marker genes. In addition, haematopoietic development is differentially affected by a variety of mutations. Here, Constanze Bonifer and colleagues discuss the existence of HSCs with specific differentiation capacities.

Original language	English
Pages (from-to)	236-241
Journal	Immunology Today
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/S0167-5699(98)01259-6
Publication status	Published - 1 May 1998

Keywords

development changes
Hematopoietic Stem Cells

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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http://dx.doi.org/10.1016/S0167-5699(98)01259-6

Cite this

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title = "Developmental changes in the differentiation capacity of hematopoietic stem cells",

abstract = "Haematopoietic stem cells (HSCs) can be found in different locations of the developing vertebrate organism. Recent studies have detected functional changes in the haematopoietic system during ontogeny. Depending on the developmental stage, HSCs create different progeny, which express distinct marker genes. In addition, haematopoietic development is differentially affected by a variety of mutations. Here, Constanze Bonifer and colleagues discuss the existence of HSCs with specific differentiation capacities.",

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AU - Geiger, H

AU - Muller, A

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AB - Haematopoietic stem cells (HSCs) can be found in different locations of the developing vertebrate organism. Recent studies have detected functional changes in the haematopoietic system during ontogeny. Depending on the developmental stage, HSCs create different progeny, which express distinct marker genes. In addition, haematopoietic development is differentially affected by a variety of mutations. Here, Constanze Bonifer and colleagues discuss the existence of HSCs with specific differentiation capacities.

KW - development changes

KW - Hematopoietic Stem Cells

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JO - Immunology Today

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Developmental changes in the differentiation capacity of hematopoietic stem cells

Abstract

Keywords

ASJC Scopus subject areas

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