Development of a fluid-structure interaction model to simulate mitral valve malcoaptation

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Development of a fluid-structure interaction model to simulate mitral valve malcoaptation. / Hassani, Kamran; Karimi, Alireza; Dehghani, Ali; Golpaygani, Ali Tavakoli; Abdi, Hamed; Espino, Daniel.

In: Perfusion, 03.11.2018.

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Hassani, Kamran ; Karimi, Alireza ; Dehghani, Ali ; Golpaygani, Ali Tavakoli ; Abdi, Hamed ; Espino, Daniel. / Development of a fluid-structure interaction model to simulate mitral valve malcoaptation. In: Perfusion. 2018.

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@article{2897fbf4210c48e8bd88c7330a10f6b5,
title = "Development of a fluid-structure interaction model to simulate mitral valve malcoaptation",
abstract = "Object:Mitral regurgitation (MR) is a condition in which the mitral valve does not prevent the reversal of blood flow from the left ventricle into the left atrium. This study aimed at numerically developing a model to mimic MR and poor leaflet coaptation and also comparing the performance of a normal mitral valve to that of the MR conditions at different gap junctions of 1, 3 and 5 mm between the anterior and posterior leaflets.Results:The results revealed no blood flow to the left ventricle when a gap between the leaflets was 0 mm. However, MR increased this blood flow, with increases in the velocity and pressure within the atrium. However, the pressure within the aorta did not vary meaningfully (ranging from 22 kPa for a {\textquoteleft}healthy{\textquoteright} model to 25 kPa for severe MR).Conclusions:The findings from this study have implications not only for understanding the changes in pressure and velocity as a result of MR in the ventricle, atrium or aorta, but also for the development of a computational model suitable for clinical translation when diagnosing and determining treatment for MR.",
author = "Kamran Hassani and Alireza Karimi and Ali Dehghani and Golpaygani, {Ali Tavakoli} and Hamed Abdi and Daniel Espino",
year = "2018",
month = nov,
day = "3",
doi = "10.1177/0267659118811045",
language = "English",
journal = "Perfusion",
issn = "0267-6591",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Development of a fluid-structure interaction model to simulate mitral valve malcoaptation

AU - Hassani, Kamran

AU - Karimi, Alireza

AU - Dehghani, Ali

AU - Golpaygani, Ali Tavakoli

AU - Abdi, Hamed

AU - Espino, Daniel

PY - 2018/11/3

Y1 - 2018/11/3

N2 - Object:Mitral regurgitation (MR) is a condition in which the mitral valve does not prevent the reversal of blood flow from the left ventricle into the left atrium. This study aimed at numerically developing a model to mimic MR and poor leaflet coaptation and also comparing the performance of a normal mitral valve to that of the MR conditions at different gap junctions of 1, 3 and 5 mm between the anterior and posterior leaflets.Results:The results revealed no blood flow to the left ventricle when a gap between the leaflets was 0 mm. However, MR increased this blood flow, with increases in the velocity and pressure within the atrium. However, the pressure within the aorta did not vary meaningfully (ranging from 22 kPa for a ‘healthy’ model to 25 kPa for severe MR).Conclusions:The findings from this study have implications not only for understanding the changes in pressure and velocity as a result of MR in the ventricle, atrium or aorta, but also for the development of a computational model suitable for clinical translation when diagnosing and determining treatment for MR.

AB - Object:Mitral regurgitation (MR) is a condition in which the mitral valve does not prevent the reversal of blood flow from the left ventricle into the left atrium. This study aimed at numerically developing a model to mimic MR and poor leaflet coaptation and also comparing the performance of a normal mitral valve to that of the MR conditions at different gap junctions of 1, 3 and 5 mm between the anterior and posterior leaflets.Results:The results revealed no blood flow to the left ventricle when a gap between the leaflets was 0 mm. However, MR increased this blood flow, with increases in the velocity and pressure within the atrium. However, the pressure within the aorta did not vary meaningfully (ranging from 22 kPa for a ‘healthy’ model to 25 kPa for severe MR).Conclusions:The findings from this study have implications not only for understanding the changes in pressure and velocity as a result of MR in the ventricle, atrium or aorta, but also for the development of a computational model suitable for clinical translation when diagnosing and determining treatment for MR.

U2 - 10.1177/0267659118811045

DO - 10.1177/0267659118811045

M3 - Article

JO - Perfusion

JF - Perfusion

SN - 0267-6591

ER -