Development and characterization of a bio-hybrid skin-like stretchable electrode

Research output: Contribution to journalArticle

Authors

  • E Buselli
  • A Smith
  • A Levi
  • R Allman
  • V Mattoli
  • A Menciassi
  • L Beccai

Colleges, School and Institutes

Abstract

This work presents the design, fabrication and characterization of a polymer based stretchable electrode for cell monitoring. The final goal is the development of innovative bio-hybrid skin-like tactile sensors with mammalian cells as core biological elements; to achieve such aim the enabling technological approach is pursued in this investigation. Electrodes are needed to detect cells response, thus the first step of the bio-hybrid system fabrication is the development of a platform able to record such response and transmit it to the external world. The stretchable electrode is composed by a conductive layer (few A of Ti plus 90 nm of Au) on a polymeric substrate (1 mm thick PDMS membrane). Cellular adhesion was verified and cellular response to an induced electrode strain of 1% was detected through fluorescence microscopy. Fluorescence intensities were 104.82 +/- 9.64 a.u. and 129.66 +/- 13.06 a.u. prior and during electrode strain, respectively. Electromechanical characterization of the stretchable electrode revealed excellent stability and reliability within the 1% strain, which is the operative range identified for the future tactile sensor application. Results showed that the electrode was conductive up to 14% of strain. Furthermore, frequency impedance measurements demonstrated the electrode capability of detecting presence of cells. (C) 2010 Elsevier B.V. All rights reserved.

Details

Original languageEnglish
Pages (from-to)1676-1680
Number of pages5
JournalMicroelectronic Engineering
Volume88
Issue number8
Publication statusPublished - 1 Aug 2011

Keywords

  • Bio-hybrid, Stretchable electrodes, Tactile sensors, Cell culture, Skin-like