TY - JOUR
T1 - Determining the parameters governing the electrochemical stability of thiols and disulfides self-assembled monolayer on gold electrodes in physiological medium
AU - Kolodziej, Adam
AU - Fernandez-Trillo, Francisco
AU - Rodriguez, Paramaconi
PY - 2017/7/20
Y1 - 2017/7/20
N2 - Herein we study the electrochemical potential-dependent and time-dependent stability of thiols and disulfides as self-assembled monolayers on gold electrodes. The stability of four representative sulfur-containing compounds: 3-mercaptopropionic acid, 2-mercaptoethanol, 1,4-dithiothreitol and dl-thioctic acid, was assessed in simulated physiological conditions (i.e. phosphate buffer saline). The stability of these molecules was evaluated using cyclic voltammetry and step-potential chronoamperometry. Coordination of the thiols and disulfides significantly affects the stability of the self-assembled monolayer. In addition, studies performed using gold single crystal (100) and (111) electrodes show the superior binding strength of the SAM on the Au(100) surface structure.
AB - Herein we study the electrochemical potential-dependent and time-dependent stability of thiols and disulfides as self-assembled monolayers on gold electrodes. The stability of four representative sulfur-containing compounds: 3-mercaptopropionic acid, 2-mercaptoethanol, 1,4-dithiothreitol and dl-thioctic acid, was assessed in simulated physiological conditions (i.e. phosphate buffer saline). The stability of these molecules was evaluated using cyclic voltammetry and step-potential chronoamperometry. Coordination of the thiols and disulfides significantly affects the stability of the self-assembled monolayer. In addition, studies performed using gold single crystal (100) and (111) electrodes show the superior binding strength of the SAM on the Au(100) surface structure.
KW - Self-assembly monolayer of thiols
KW - disulfides
KW - electrochemistry
KW - desorption
KW - surface structure
U2 - 10.1016/j.jelechem.2017.07.039
DO - 10.1016/j.jelechem.2017.07.039
M3 - Article
SN - 1572-6657
JO - Journal of Electroanalytical Chemistry
JF - Journal of Electroanalytical Chemistry
ER -