Determination of the extracellular glycine concentration in the rat spinal cord dorsal horn by quantitative microdialysis

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Colleges, School and Institutes


Two quantitative microdialysis methods were used to determine the extracellular concentration of glycine in the dorsal spinal cord of halothane-anaesthetised rats. Extracellular glycine determined by zero net flux was 2.6+/-0.3 microM and by the zero flow method was 3.3+/-0.3 microM. For comparison the glycine content of cerebrospinal fluid was determined to be 6.4+/-1.1 microM. There was no correlation between the extracellular and the cerebrospinal fluid concentrations.


Original languageEnglish
Pages (from-to)192-194
Number of pages3
JournalBrain Research
Issue number1-2
Publication statusPublished - 10 Aug 2001


  • extracellular concentration, quantitative microdialysis, glycine, spinal cord dorsal horn, glycine transporter