Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe
Research output: Contribution to journal › Article
Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the synthesised target sequences, probe-target duplex formation could lead to enhanced or attenuated fluorescence emission from the anthracene, enabling detection of a proximal base-pair as either matching or mismatching.
|Number of pages||4|
|Journal||Bioorganic & Medicinal Chemistry Letters|
|Publication status||Published - 1 Jan 2012|
- DNA, SNP, Fluorescence, Sensing, Nucleic acids