Detection of intestinal metaplasia in Barrett's esophagus: an observational comparator study suggests the need for a minimum of eight biopsies

Research output: Contribution to journalArticle


  • Rebecca Harrison
  • William Haddadin
  • Stuart McDonald
  • Keith Abrams
  • Richard Sampliner
  • Nicholas J Talley

Colleges, School and Institutes


Intestinal metaplasia (IM) and dysplasia in Barrett's esophagus are recognized surrogates for esophageal adenocarcinoma risk. While few would argue with the "hunt for dysplasia," there is a divide regarding the usefulness of the histological confirmation of intestinal metaplasia in endoscopically apparent long segment Barrett's esophagus. We aimed to assess the frequency of intestinal metaplasia in 125 consecutive patients with columnar-lined esophagus and to determine the optimal biopsy protocol to detect intestinal metaplasia.


Original languageEnglish
Pages (from-to)1154-61
Number of pages8
JournalThe American Journal of Gastroenterology
Issue number6
Publication statusPublished - 2007