Detection of branch retinal artery occlusions in Susac's syndrome

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Detection of branch retinal artery occlusions in Susac's syndrome. / Boukouvala, Stavroula; Jacob, Saiju; Lane, Mark; Denniston, Alastair K; Burdon, Michael A.

In: BMC Research Notes, Vol. 7, 21.01.2014, p. 56.

Research output: Contribution to journalArticlepeer-review

Harvard

Boukouvala, S, Jacob, S, Lane, M, Denniston, AK & Burdon, MA 2014, 'Detection of branch retinal artery occlusions in Susac's syndrome', BMC Research Notes, vol. 7, pp. 56. https://doi.org/10.1186/1756-0500-7-56

APA

Boukouvala, S., Jacob, S., Lane, M., Denniston, A. K., & Burdon, M. A. (2014). Detection of branch retinal artery occlusions in Susac's syndrome. BMC Research Notes, 7, 56. https://doi.org/10.1186/1756-0500-7-56

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Boukouvala, Stavroula ; Jacob, Saiju ; Lane, Mark ; Denniston, Alastair K ; Burdon, Michael A. / Detection of branch retinal artery occlusions in Susac's syndrome. In: BMC Research Notes. 2014 ; Vol. 7. pp. 56.

Bibtex

@article{4d0f43cd0fa946ffbb6b23e3a409b8ca,
title = "Detection of branch retinal artery occlusions in Susac's syndrome",
abstract = "BACKGROUND: We report an interesting case of asymptomatic retinal involvement in an encephalopathic patient enabling early identification of Susac's syndrome.CASE PRESENTATION: A 39-year-old Caucasian lady with hearing loss and encephalopathy was referred for ophthalmic assessment, including screening for branch retinal artery occlusions characteristic of Susac's syndrome. Clinical features included severe headaches, right-sided hypoacusis, dysphasia and poor memory. Routine blood tests were normal. MRI brain showed numerous hyperintense lesions mainly in corpus callosum. Although she was visually asymptomatic, dilated funduscopy detected bilateral multiple peripheral branch retinal artery occlusions which were confirmed on fluorescein angiography. She was subsequently started on intravenous steroids and pulsed cyclophosphamide which improved her symptoms within 48 hours. Full recovery was made with no new arterial occlusions on four months follow-up.CONCLUSION: The case further establishes the crucial role of a detailed ophthalmic examination supported by fluorescein angiography in the assessment of these patients, who are at risk of being misdiagnosed and undertreated.",
keywords = "Adult, Corpus Callosum/pathology, Cyclophosphamide/therapeutic use, Drug Therapy, Combination, Female, Fluorescein Angiography, Headache/etiology, Hearing Loss, Central/etiology, Humans, Immunosuppressive Agents/therapeutic use, Magnetic Resonance Imaging, Memory Disorders/etiology, Methylprednisolone/therapeutic use, Ophthalmoscopy, Retinal Artery Occlusion/diagnosis, Susac Syndrome/complications, Vertigo/etiology",
author = "Stavroula Boukouvala and Saiju Jacob and Mark Lane and Denniston, {Alastair K} and Burdon, {Michael A}",
year = "2014",
month = jan,
day = "21",
doi = "10.1186/1756-0500-7-56",
language = "English",
volume = "7",
pages = "56",
journal = "BMC Research Notes",
issn = "1756-0500",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Detection of branch retinal artery occlusions in Susac's syndrome

AU - Boukouvala, Stavroula

AU - Jacob, Saiju

AU - Lane, Mark

AU - Denniston, Alastair K

AU - Burdon, Michael A

PY - 2014/1/21

Y1 - 2014/1/21

N2 - BACKGROUND: We report an interesting case of asymptomatic retinal involvement in an encephalopathic patient enabling early identification of Susac's syndrome.CASE PRESENTATION: A 39-year-old Caucasian lady with hearing loss and encephalopathy was referred for ophthalmic assessment, including screening for branch retinal artery occlusions characteristic of Susac's syndrome. Clinical features included severe headaches, right-sided hypoacusis, dysphasia and poor memory. Routine blood tests were normal. MRI brain showed numerous hyperintense lesions mainly in corpus callosum. Although she was visually asymptomatic, dilated funduscopy detected bilateral multiple peripheral branch retinal artery occlusions which were confirmed on fluorescein angiography. She was subsequently started on intravenous steroids and pulsed cyclophosphamide which improved her symptoms within 48 hours. Full recovery was made with no new arterial occlusions on four months follow-up.CONCLUSION: The case further establishes the crucial role of a detailed ophthalmic examination supported by fluorescein angiography in the assessment of these patients, who are at risk of being misdiagnosed and undertreated.

AB - BACKGROUND: We report an interesting case of asymptomatic retinal involvement in an encephalopathic patient enabling early identification of Susac's syndrome.CASE PRESENTATION: A 39-year-old Caucasian lady with hearing loss and encephalopathy was referred for ophthalmic assessment, including screening for branch retinal artery occlusions characteristic of Susac's syndrome. Clinical features included severe headaches, right-sided hypoacusis, dysphasia and poor memory. Routine blood tests were normal. MRI brain showed numerous hyperintense lesions mainly in corpus callosum. Although she was visually asymptomatic, dilated funduscopy detected bilateral multiple peripheral branch retinal artery occlusions which were confirmed on fluorescein angiography. She was subsequently started on intravenous steroids and pulsed cyclophosphamide which improved her symptoms within 48 hours. Full recovery was made with no new arterial occlusions on four months follow-up.CONCLUSION: The case further establishes the crucial role of a detailed ophthalmic examination supported by fluorescein angiography in the assessment of these patients, who are at risk of being misdiagnosed and undertreated.

KW - Adult

KW - Corpus Callosum/pathology

KW - Cyclophosphamide/therapeutic use

KW - Drug Therapy, Combination

KW - Female

KW - Fluorescein Angiography

KW - Headache/etiology

KW - Hearing Loss, Central/etiology

KW - Humans

KW - Immunosuppressive Agents/therapeutic use

KW - Magnetic Resonance Imaging

KW - Memory Disorders/etiology

KW - Methylprednisolone/therapeutic use

KW - Ophthalmoscopy

KW - Retinal Artery Occlusion/diagnosis

KW - Susac Syndrome/complications

KW - Vertigo/etiology

U2 - 10.1186/1756-0500-7-56

DO - 10.1186/1756-0500-7-56

M3 - Article

C2 - 24447473

VL - 7

SP - 56

JO - BMC Research Notes

JF - BMC Research Notes

SN - 1756-0500

ER -