Detection of bacterial DNA in cardiac vegetations by PCR after the completion of antimicrobial treatment for endocarditis

Research output: Contribution to journalArticle

Standard

Detection of bacterial DNA in cardiac vegetations by PCR after the completion of antimicrobial treatment for endocarditis. / Lang, S; Watkin, Richard; Lambert, PA; Littler, William; Elliott, Thomas.

In: Clinical Microbiology and Infection, Vol. 10, 01.01.2004, p. 579-581.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Bibtex

@article{d2228b5231fe4471ba835d420a4086be,
title = "Detection of bacterial DNA in cardiac vegetations by PCR after the completion of antimicrobial treatment for endocarditis",
abstract = "PCR with broad-range primers for prokaryotic 16S rRNA genes was used to identify bacterial DNA in tissue from patients undergoing valve replacements following a previous episode of infective endocarditis (IE). Of eight valves investigated, bacterial DNA was detected in three from patients for whom IE had been treated by antibiotic therapy 5, 12 and 18 months previously. The demonstration of bacterial DNA within resected heart valves suggests either recurrence of infection, treatment failure or the persistence of bacterial debris within the cardiac vegetation. There may also be implications for routine use of PCR in the diagnosis of infection.",
author = "S Lang and Richard Watkin and PA Lambert and William Littler and Thomas Elliott",
year = "2004",
month = jan,
day = "1",
doi = "10.1111/j.1198-743X.2004.00821.x",
language = "English",
volume = "10",
pages = "579--581",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Detection of bacterial DNA in cardiac vegetations by PCR after the completion of antimicrobial treatment for endocarditis

AU - Lang, S

AU - Watkin, Richard

AU - Lambert, PA

AU - Littler, William

AU - Elliott, Thomas

PY - 2004/1/1

Y1 - 2004/1/1

N2 - PCR with broad-range primers for prokaryotic 16S rRNA genes was used to identify bacterial DNA in tissue from patients undergoing valve replacements following a previous episode of infective endocarditis (IE). Of eight valves investigated, bacterial DNA was detected in three from patients for whom IE had been treated by antibiotic therapy 5, 12 and 18 months previously. The demonstration of bacterial DNA within resected heart valves suggests either recurrence of infection, treatment failure or the persistence of bacterial debris within the cardiac vegetation. There may also be implications for routine use of PCR in the diagnosis of infection.

AB - PCR with broad-range primers for prokaryotic 16S rRNA genes was used to identify bacterial DNA in tissue from patients undergoing valve replacements following a previous episode of infective endocarditis (IE). Of eight valves investigated, bacterial DNA was detected in three from patients for whom IE had been treated by antibiotic therapy 5, 12 and 18 months previously. The demonstration of bacterial DNA within resected heart valves suggests either recurrence of infection, treatment failure or the persistence of bacterial debris within the cardiac vegetation. There may also be implications for routine use of PCR in the diagnosis of infection.

UR - http://www.scopus.com/inward/record.url?scp=3242674329&partnerID=8YFLogxK

U2 - 10.1111/j.1198-743X.2004.00821.x

DO - 10.1111/j.1198-743X.2004.00821.x

M3 - Article

C2 - 15191390

VL - 10

SP - 579

EP - 581

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

ER -