Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe

Nina Moran; DM Bassani; J-P Desvergne; S Keiper; PAS Lowden; JS Vyle; James Tucker

doi:10.1039/b611650g

Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe

Nina Moran, DM Bassani, J-P Desvergne, S Keiper, PAS Lowden, JS Vyle, James Tucker

Chemistry

Research output: Contribution to journal › Article

34 Citations (Scopus)

Abstract

A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.

Original language	English
Pages (from-to)	5003-5005
Number of pages	3
Journal	Chemical Communications
Volume	2006
DOIs	https://doi.org/10.1039/b611650g
Publication status	Published - 1 Jan 2006

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10.1039/b611650g

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title = "Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe",

abstract = "A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.",

author = "Nina Moran and DM Bassani and J-P Desvergne and S Keiper and PAS Lowden and JS Vyle and James Tucker",

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AU - Moran, Nina

AU - Bassani, DM

AU - Desvergne, J-P

AU - Keiper, S

AU - Lowden, PAS

AU - Vyle, JS

AU - Tucker, James

PY - 2006/1/1

Y1 - 2006/1/1

N2 - A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.

AB - A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.

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U2 - 10.1039/b611650g

DO - 10.1039/b611650g

M3 - Article

SN - 1364-548X

VL - 2006

SP - 5003

EP - 5005

JO - Chemical Communications

JF - Chemical Communications

ER -

Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe

Abstract

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