Detecting inflammation in rheumatoid arthritis using Fourier transform analysis of dorsal optical transmission images from a pilot study
Research output: Contribution to journal › Article
A clinical need exists for novel, low-cost and non-invasive imaging tools capable of detecting inflammation in the joints of inflammatory arthritis patients. Previous studies have reported an optical contrast between inflamed and non-inflamed joints resulting from distinct absorption and scattering properties. Accurate classification using non occlusion based continuous wave, transillumination imaging was limited to patient specific changes during follow-up examination as opposed to single time-point examination, which was attributed to high inter-subject variability. In distinction from previous work, optical images were acquired from the dorsal side with illumination on the palmar side and features about the spatial distribution of transmitted light along the joint were assessed using a normalised Fourier transform method. Results using this approach demonstrated an area under receiver operator curve of up to 0.888 for detecting inflammation in a pilot study involving single time-point examination of 144 joints from 21 rheumatology patients. This work-flow may enable future development of clinically viable, low-cost devices for assessing inflammation in arthritis patients, without the need for cuff occlusion or comparison to baseline.
|Number of pages||35|
|Journal||Journal of Biomedical Optics|
|Early online date||20 Jun 2019|
|Publication status||E-pub ahead of print - 20 Jun 2019|
- optical imaging, rheumatoid arthritis, intrinsic contrast