Desmosomal cadherins

Martyn Chidgey; David Garrod

doi:10.1007/978-4-431-56033-3_7

Desmosomal cadherins

Martyn Chidgey, David Garrod

Clinical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

The desmosomal cadherins (DCs) are adhesion molecules of desmosomes,
intercellular junctions of epithelia and cardiac muscle. DCs have the unique
ability to adopt a hyperadhesive state that is characterised by enhanced stability and adhesive strength. Hyperadhesion is important in embryonic development and wound healing, and DC expression is tightly regulated at the transcriptional and posttranslational levels. Desmosomes act as signalling centres and DCs have been linked to an array of intracellular signal transduction pathways that control cell proliferation and differentiation. DCs are targets of autoantibodies, bacterial toxins and mutations, resulting in skin blistering disease, cardiomyopathy and sometimes both. Here we consider the structure and function of the desmosomal cadherins, and their role in normal tissue biology and human disease.

Original language	English
Title of host publication	The Cadherin Superfamily
Subtitle of host publication	Key Regulators of Animal Development and Physiology
Editors	Shintaro T Suzuki, Shinji Hirano
Publisher	Springer
Pages	159-193
Number of pages	35
ISBN (Electronic)	9784431560333
ISBN (Print)	9784431560319
DOIs	https://doi.org/10.1007/978-4-431-56033-3_7
Publication status	Published - 2016

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abstract = "The desmosomal cadherins (DCs) are adhesion molecules of desmosomes,intercellular junctions of epithelia and cardiac muscle. DCs have the uniqueability to adopt a hyperadhesive state that is characterised by enhanced stability and adhesive strength. Hyperadhesion is important in embryonic development and wound healing, and DC expression is tightly regulated at the transcriptional and posttranslational levels. Desmosomes act as signalling centres and DCs have been linked to an array of intracellular signal transduction pathways that control cell proliferation and differentiation. DCs are targets of autoantibodies, bacterial toxins and mutations, resulting in skin blistering disease, cardiomyopathy and sometimes both. Here we consider the structure and function of the desmosomal cadherins, and their role in normal tissue biology and human disease.",

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AU - Garrod, David

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AB - The desmosomal cadherins (DCs) are adhesion molecules of desmosomes,intercellular junctions of epithelia and cardiac muscle. DCs have the uniqueability to adopt a hyperadhesive state that is characterised by enhanced stability and adhesive strength. Hyperadhesion is important in embryonic development and wound healing, and DC expression is tightly regulated at the transcriptional and posttranslational levels. Desmosomes act as signalling centres and DCs have been linked to an array of intracellular signal transduction pathways that control cell proliferation and differentiation. DCs are targets of autoantibodies, bacterial toxins and mutations, resulting in skin blistering disease, cardiomyopathy and sometimes both. Here we consider the structure and function of the desmosomal cadherins, and their role in normal tissue biology and human disease.

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DO - 10.1007/978-4-431-56033-3_7

M3 - Chapter

SN - 9784431560319

SP - 159

EP - 193

BT - The Cadherin Superfamily

A2 - Suzuki, Shintaro T

A2 - Hirano, Shinji

PB - Springer

ER -

Desmosomal cadherins

Abstract

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