Abstract
The design of a hemofiltration method that minimizes the side effects produced by the accumulation of Pt-based drugs such as cisplatin represents an important technology for cancer treatment. This work establishes the foundation for the development of an efficient platform for the electrochemical hemofiltration and simultaneous sensing of antitumor drugs, such as cisplatin and carboplatin, from physiological medium. The electrochemical filtration system is based on a gold surface-modified electrode using tris(carboxyethyl)phosphine ligands as scavengers of the Pt-based drug complexes. The platinum-phosphine interaction is shown to be more time efficient, as compared to the naturally occurring form of a glutathione-platinum adduct, and displayed a highly cooperative nature of binding. Altogether, we demonstrate that the presence of ligands capable of binding to Pt results in a differential spectroscopic and electrochemical response and the potential to adsorb and monitor the concentration of Pt salts in complex aqueous media.
| Original language | English |
|---|---|
| Pages (from-to) | 8012-8018 |
| Number of pages | 7 |
| Journal | Chemistry of Materials |
| Volume | 31 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 8 Oct 2019 |
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
- Materials Chemistry
Access to Document
- Kolodziej_et_al_Design_of_surface-modified_electrodes_for_the_electrochemical_adsorption_of_Platinum-based_anticancer_drugs_Chemistry_of_Materials_2019
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.chemmater.9b02382