Design and material evaluation for a novel lumbar disc replacement implanted via unilateral transforaminal approach

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@article{c5d6029a0bf54523be9ef8e1a35cc104,
title = "Design and material evaluation for a novel lumbar disc replacement implanted via unilateral transforaminal approach",
abstract = "The degeneration of the intervertebral disc is one of the principal causes of low back pain. Total disc replacement is a surgical treatment that aims to replace the degenerated disc with a dynamic implant to restore spine biomechanics. This paper proposes the first design of an elastomeric lumbar disc replacement that is implanted as a pair of devices via unilateral transforaminal surgical approach. Furthermore, several biomaterials (Polyurethanes (PU) and Polycarbonate Urethanes (PCU)) are evaluated for the purpose of the implant to mimic the axial compliance of the spine. Bionate II 80 A (a pure PCU), Elast Eon 82 A E5–325 (a PU with polydimethylsiloxane and polyhexamethylene oxide), Chronosil (a PCU based silicone elastomer) 80 A with 5% and 10% of silicone were obtained and injection moulded according to the shape of the implant core, which was defined after a stress distribution analysis with the finite element method. The dimensions for each specimen were: 14.6 ×5.6 ×6.1 mm (length, width and height). Quasistatic compression tests were performed at a displacement rate of 0.02 mm/s. The obtained stiffness for each material at 1 mm displacement was: Bionate II 80 A, 448.48 N/mm; Elast Eon 82 A E5–325, 216.55 N/mm; Chronosil 80 A 5%, 127.73 N/mm; and Chronosil 80 A 10%, 126.48 N/mm. Dimensional changes were quantified after two quasi-static compression tests. Plastic deformation was perceived in all cases with a total percentage of height loss of: 4.1 ± 0.5% for Elast Eon 82 A E5–325; 3.2 ± 0.5% for Chronosil 80 A 10%; 2.7 ± 0.3% for Chronosil 80 A 5% and 1.1 ± 0.2% for Bionate II 80 A. The mechanical behavior of these biomaterials is discussed to assess their suitability for the novel disc replacement device proposed.",
keywords = "polyurethane biomaterials, polycarbonate urethane biomaterials, siffness, deformation, elastomeric lumbar disc replacement, Polycarbonate urethane biomaterials, stiffness, Elastomeric lumbar disc replacement, Deformation, Polyurethane biomaterials",
author = "{Gonzalez Alvarez}, Alba and Karl Dearn and Duncan Shepherd",
year = "2019",
month = mar,
doi = "10.1016/j.jmbbm.2018.12.011",
language = "English",
volume = "91",
pages = "383--390",
journal = "Journal of the Mechanical Behavior of Biomedical Materials",
issn = "1751-6161",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Design and material evaluation for a novel lumbar disc replacement implanted via unilateral transforaminal approach

AU - Gonzalez Alvarez, Alba

AU - Dearn, Karl

AU - Shepherd, Duncan

PY - 2019/3

Y1 - 2019/3

N2 - The degeneration of the intervertebral disc is one of the principal causes of low back pain. Total disc replacement is a surgical treatment that aims to replace the degenerated disc with a dynamic implant to restore spine biomechanics. This paper proposes the first design of an elastomeric lumbar disc replacement that is implanted as a pair of devices via unilateral transforaminal surgical approach. Furthermore, several biomaterials (Polyurethanes (PU) and Polycarbonate Urethanes (PCU)) are evaluated for the purpose of the implant to mimic the axial compliance of the spine. Bionate II 80 A (a pure PCU), Elast Eon 82 A E5–325 (a PU with polydimethylsiloxane and polyhexamethylene oxide), Chronosil (a PCU based silicone elastomer) 80 A with 5% and 10% of silicone were obtained and injection moulded according to the shape of the implant core, which was defined after a stress distribution analysis with the finite element method. The dimensions for each specimen were: 14.6 ×5.6 ×6.1 mm (length, width and height). Quasistatic compression tests were performed at a displacement rate of 0.02 mm/s. The obtained stiffness for each material at 1 mm displacement was: Bionate II 80 A, 448.48 N/mm; Elast Eon 82 A E5–325, 216.55 N/mm; Chronosil 80 A 5%, 127.73 N/mm; and Chronosil 80 A 10%, 126.48 N/mm. Dimensional changes were quantified after two quasi-static compression tests. Plastic deformation was perceived in all cases with a total percentage of height loss of: 4.1 ± 0.5% for Elast Eon 82 A E5–325; 3.2 ± 0.5% for Chronosil 80 A 10%; 2.7 ± 0.3% for Chronosil 80 A 5% and 1.1 ± 0.2% for Bionate II 80 A. The mechanical behavior of these biomaterials is discussed to assess their suitability for the novel disc replacement device proposed.

AB - The degeneration of the intervertebral disc is one of the principal causes of low back pain. Total disc replacement is a surgical treatment that aims to replace the degenerated disc with a dynamic implant to restore spine biomechanics. This paper proposes the first design of an elastomeric lumbar disc replacement that is implanted as a pair of devices via unilateral transforaminal surgical approach. Furthermore, several biomaterials (Polyurethanes (PU) and Polycarbonate Urethanes (PCU)) are evaluated for the purpose of the implant to mimic the axial compliance of the spine. Bionate II 80 A (a pure PCU), Elast Eon 82 A E5–325 (a PU with polydimethylsiloxane and polyhexamethylene oxide), Chronosil (a PCU based silicone elastomer) 80 A with 5% and 10% of silicone were obtained and injection moulded according to the shape of the implant core, which was defined after a stress distribution analysis with the finite element method. The dimensions for each specimen were: 14.6 ×5.6 ×6.1 mm (length, width and height). Quasistatic compression tests were performed at a displacement rate of 0.02 mm/s. The obtained stiffness for each material at 1 mm displacement was: Bionate II 80 A, 448.48 N/mm; Elast Eon 82 A E5–325, 216.55 N/mm; Chronosil 80 A 5%, 127.73 N/mm; and Chronosil 80 A 10%, 126.48 N/mm. Dimensional changes were quantified after two quasi-static compression tests. Plastic deformation was perceived in all cases with a total percentage of height loss of: 4.1 ± 0.5% for Elast Eon 82 A E5–325; 3.2 ± 0.5% for Chronosil 80 A 10%; 2.7 ± 0.3% for Chronosil 80 A 5% and 1.1 ± 0.2% for Bionate II 80 A. The mechanical behavior of these biomaterials is discussed to assess their suitability for the novel disc replacement device proposed.

KW - polyurethane biomaterials

KW - polycarbonate urethane biomaterials

KW - siffness

KW - deformation

KW - elastomeric lumbar disc replacement

KW - Polycarbonate urethane biomaterials, stiffness

KW - Elastomeric lumbar disc replacement

KW - Deformation

KW - Polyurethane biomaterials

UR - http://www.scopus.com/inward/record.url?scp=85059959048&partnerID=8YFLogxK

U2 - 10.1016/j.jmbbm.2018.12.011

DO - 10.1016/j.jmbbm.2018.12.011

M3 - Article

VL - 91

SP - 383

EP - 390

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

SN - 1751-6161

ER -