Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides
Research output: Contribution to journal › Article
Authors
Colleges, School and Institutes
Abstract
Di-nuclear metallo-supramolecular "cylinders", based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 784-792 |
| Number of pages | 9 |
| Journal | Inorganica Chimica Acta |
| Volume | 362 |
| Issue number | 3 |
| Publication status | Published - 1 Feb 2009 |
Keywords
- DNA-binding, Supramolecular cylinders, Artificial nuclease, Peptide functionalisation, DNA coiling, Bioinorganic chemistry, Metallo-supramolecular chemistry