Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis

Arathyram Ramachandra Kurup Sasikala; Afeesh Rajan Unnithan; Chan Hee Park; Cheol Sang Kim

doi:10.1039/c5tb02011e

Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis

Arathyram Ramachandra Kurup Sasikala, Afeesh Rajan Unnithan, Chan Hee Park, Cheol Sang Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core–shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX–MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.

Original language	English
Pages (from-to)	785-792
Journal	J. Mater. Chem. B
Issue number	4
DOIs	https://doi.org/10.1039/c5tb02011e
Publication status	Published - 2016

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title = "Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis",

abstract = "Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core–shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX–MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.",

author = "Sasikala, {Arathyram Ramachandra Kurup} and Unnithan, {Afeesh Rajan} and Park, {Chan Hee} and Kim, {Cheol Sang}",

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AU - Sasikala, Arathyram Ramachandra Kurup

AU - Unnithan, Afeesh Rajan

AU - Park, Chan Hee

AU - Kim, Cheol Sang

PY - 2016

Y1 - 2016

N2 - Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core–shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX–MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.

AB - Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core–shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX–MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.

U2 - 10.1039/c5tb02011e

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Design and application of a smart nanodevice by combining cationic drug delivery and hyperthermia for cancer apoptosis

Abstract

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